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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Redmile Group LLC	[2025-06-30]	SOLE	2,074,372	2,074,372
BML Capital Management LLC	[2025-06-30]	SOLE	0	1,970,610
Sanofi	[2025-06-30]	SOLE	1,919,455	1,919,455
Merck & Co., Inc.	[2025-06-30]	DFND	0	1,149,345
Bruce & Co Inc	[2025-06-30]	SOLE	521,874	521,874
Pathway Financial Advisors LLC	[2025-06-30]	SOLE	0	102,500
Citadel Advisors LLC	[2025-06-30]	DFND	69,604	69,604
PNC Financial Services Group Inc	[2025-06-30]	DFND	65,000	65,000
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	46,900
Two Sigma Investments LP	[2025-06-30]	SOLE	34,412	34,412
Lepercq de Neuflize Asset Management LLC	[2025-06-30]	SOLE	31,000	31,000
Rangeley Capital LLC	[2025-06-30]	SOLE	27,073	27,073
UBS Group AG	[2025-06-30]	DFND	16,380	16,380
Two Sigma Securities LLC	[2025-06-30]	SOLE	14,236	14,236
Geode Capital Management LLC	[2025-06-30]	DFND	14,170	14,170
Morgan Stanley	[2025-06-30]	DFND	11,600	11,600
Jones Financial Companies LLLP	[2025-06-30]	SOLE	400	400
TSFG LLC	[2025-06-30]	SOLE	0	400
SBI Securities Co., Ltd.	[2025-06-30]	DFND	300	300
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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