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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	5,985,347	5,985,347
OrbiMed Advisors LLC	[2025-06-30]	SOLE	4,002,887	4,002,887
NEA Management Company LLC	[2025-06-30]	DFND	3,614,486	3,614,486
Wellington Management Group LLP	[2025-06-30]	DFND	0	2,266,628
Deep Track Capital LP	[2025-06-30]	SOLE	2,188,592	2,188,592
NVP Associates, LLC	[2025-06-30]	SOLE	2,136,335	2,136,335
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,417,475	1,571,906
MPM BioImpact LLC	[2025-06-30]	SOLE	1,294,416	1,294,416
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,149,794	1,149,794
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,030,925
BlackRock, Inc.	[2025-06-30]	SOLE	984,686	1,011,546
Point72 Asset Management LP	[2025-06-30]	DFND	0	973,787
Woodline Partners LP	[2025-06-30]	SOLE	901,103	901,103
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	871,933	871,933
Millennium Management LLC	[2025-06-30]	SOLE	766,840	818,140
Cormorant Asset Management LP	[2025-06-30]	DFND	700,000	700,000
TCG Crossover Management LLC	[2025-06-30]	SOLE	650,000	650,000
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	631,413	631,413
Franklin Resources Inc	[2025-06-30]	DFND	494,852	494,852
RA Capital Management LP	[2025-06-30]	SOLE	377,841	377,841
Geode Capital Management LLC	[2025-06-30]	DFND	348,447	348,447
State Street Corp	[2025-06-30]	DFND	246,919	265,119
SIO Capital Management LLC	[2025-06-30]	SOLE	241,000	241,000
Opaleye Management Inc	[2025-06-30]	SOLE	239,319	239,319
Sectoral Asset Management Inc	[2025-06-30]	SOLE	0	191,825
TD Asset Management Inc	[2025-06-30]	SOLE	171,304	171,304
Stempoint Capital LP	[2025-06-30]	SOLE	141,021	141,021
Northern Trust Corp	[2025-06-30]	DFND	112,986	112,986
Platinum Investment Management Ltd	[2025-06-30]	SOLE	112,743	112,743
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	107,483	107,483
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