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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	7,490,283	7,490,377
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	4,281,954	4,281,954
RTW Investments LP	[2025-06-30]	SOLE	4,000,553	4,000,553
Wellington Management Group LLP	[2025-06-30]	DFND	0	3,726,723
Commodore Capital LP	[2025-06-30]	SOLE	3,525,000	3,525,000
Deerfield Management Company LP	[2025-06-30]	DFND	3,384,628	3,384,628
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	3,155,555	3,155,555
Holocene Advisors LP	[2025-06-30]	SOLE	2,225,241	2,225,241
Westfield Capital Management Co LP	[2025-06-30]	SOLE	1,440,337	2,042,388
Franklin Resources Inc	[2025-06-30]	DFND	1,837,575	1,837,575
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,611,049	1,611,049
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	1,568,841
Woodline Partners LP	[2025-06-30]	SOLE	1,542,900	1,542,900
Federated Hermes Inc	[2025-06-30]	DFND	1,528,587	1,528,587
Driehaus Capital Management LLC	[2025-06-30]	SOLE	932,838	1,366,244
Ameriprise Financial Inc	[2025-06-30]	DFND	0	1,133,857
Cormorant Asset Management LP	[2025-06-30]	DFND	1,120,000	1,120,000
AllianceBernstein LP	[2025-06-30]	DFND	1,032,785	1,102,356
Rock Springs Capital Management LP	[2025-06-30]	SOLE	1,063,608	1,063,608
BlackRock, Inc.	[2025-06-30]	SOLE	997,025	1,050,942
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	825,662	915,252
Siren, L.L.C.	[2025-06-30]	DFND	853,467	853,467
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	833,397	833,397
Invesco Ltd.	[2025-06-30]	DFND	0	833,361
Janus Henderson Group PLC	[2025-06-30]	DFND	0	829,558
Samlyn Capital LLC	[2025-06-30]	DFND	765,185	765,185
Novo Holdings A/S	[2025-06-30]	SOLE	750,000	750,000
SilverArc Capital Management LLC	[2025-06-30]	SOLE	741,972	741,972
Perceptive Advisors LLC	[2025-06-30]	SOLE	708,176	708,176
JPMorgan Chase & Co	[2025-06-30]	DFND	690,945	690,945
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