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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bellevue Group AG	[2023-03-31]	DFND	11,230,003.0	11,230,003.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	4,996,565.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,196,888.0
Caxton Corp	[2023-03-31]	SOLE	2,052,991.0	2,052,991.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	1,200,000.0	1,200,000.0
BlackRock Inc.	[2023-03-31]	SOLE	747,467.0	748,310.0
Geode Capital Management LLC	[2023-03-31]	DFND	395,829.0	395,829.0
Millennium Management LLC	[2023-03-31]	SOLE	290,859.0	290,859.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	204,090.0	254,814.0
Acadian Asset Management LLC	[2023-03-31]	DFND	234,497.0	234,497.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	200,000.0
State Street Corp	[2023-03-31]	DFND	140,681.0	140,681.0
Morgan Stanley	[2023-03-31]	DFND	106,778.0	107,423.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	93,601.0
Herbst Group LLC	[2023-03-31]	SOLE	0.0	48,500.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	40,180.0	40,180.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	35,685.0	35,685.0
Mackenzie Financial Corp	[2023-03-31]	SOLE	25,431.0	25,431.0
Rockefeller Capital Management L.P.	[2023-03-31]	DFND	23,001.0	23,001.0
Prudential Financial Inc	[2023-03-31]	DFND	10,827.0	21,182.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	20,095.0	20,095.0
Oppenheimer & Co Inc	[2023-03-31]	SOLE	20,000.0	20,000.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	15,167.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	10,000.0	10,000.0
Baader Bank Aktiengesellschaft	[2023-03-31]	SOLE	10,000.0	10,000.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	7,715.0
Barclays PLC	[2023-03-31]	SOLE	5,631.0	5,631.0
Advisor Group Holdings Inc	[2023-03-31]	DFND	0.0	4,191.0
Federated Hermes Inc	[2023-03-31]	DFND	3,768.0	3,768.0
TSFG LLC	[2023-03-31]	SOLE	0.0	1,000.0
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