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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	32,670,402.0	32,670,482.0
Omega Fund Management LLC	[2023-03-31]	SOLE	15,072,340.0	15,072,340.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	13,896,543.0	13,896,543.0
BlackRock Inc.	[2023-03-31]	SOLE	10,886,271.0	11,197,771.0
Deep Track Capital LP	[2023-03-31]	SOLE	7,720,688.0	7,720,688.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	7,029,718.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	5,854,860.0	5,854,860.0
Braidwell LP	[2023-03-31]	SOLE	4,122,900.0	4,122,900.0
Abrams Capital Management LP	[2023-03-31]	SOLE	3,811,513.0	3,811,513.0
Redmile Group LLC	[2023-03-31]	SOLE	3,031,009.0	3,031,009.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,859,970.0	2,859,970.0
State Street Corp	[2023-03-31]	DFND	2,637,751.0	2,793,407.0
Aisling Capital Management LP	[2023-03-31]	SOLE	2,541,009.0	2,541,009.0
Geode Capital Management LLC	[2023-03-31]	DFND	2,388,275.0	2,388,275.0
683 Capital Management LLC	[2023-03-31]	DFND	2,100,000.0	2,100,000.0
AWM Investment Company Inc	[2023-03-31]	SOLE	1,525,000.0	1,525,000.0
Farallon Capital Management LLC	[2023-03-31]	OTR	1,465,000.0	1,465,000.0
EDBI Pte Ltd	[2023-03-31]	SOLE	1,270,504.0	1,270,504.0
Northern Trust Corp	[2023-03-31]	DFND	60,389.0	1,072,547.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	953,801.0	953,801.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	793,238.0	793,238.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	137,728.0	684,149.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	550,600.0	628,200.0
Bank of America Corp /DE/	[2023-03-31]	DFND	15,497.0	507,452.0
Clearline Capital LP	[2023-03-31]	SOLE	494,506.0	494,506.0
Millennium Management LLC	[2023-03-31]	SOLE	488,289.0	488,289.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	482,233.0	482,233.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	363,517.0	455,159.0
Two Sigma Investments LP	[2023-03-31]	SOLE	452,055.0	452,055.0
Morgan Stanley	[2023-03-31]	DFND	410,829.0	448,641.0
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