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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Tang Capital Management LLC	[2020-09-30]	OTR	0.0	15.2
Boxer Capital, LLC	[2020-09-30]	OTR	5.2	5.2
Wellington Management Group LLP	[2020-09-30]	DFND	0.0	4.5
Janus Henderson Group PLC	[2020-09-30]	DFND	0.0	2.6
Driehaus Capital Management LLC	[2020-09-30]	SOLE	1.1	1.2
RTW Investments LP	[2020-09-30]	SOLE	1.0	1.0
BlackRock Inc.	[2020-09-30]	SOLE	0.9	0.9
Samsara Biocapital LLC	[2020-09-30]	SOLE	0.8	0.8
Vanguard Group Inc	[2020-09-30]	SOLE	0.0	0.7
Rock Springs Capital Management LP	[2020-09-30]	SOLE	0.5	0.5
Price T Rowe Associates Inc /MD/	[2020-09-30]	SOLE	0.1	0.5
Two Sigma Investments LP	[2020-09-30]	SOLE	0.3	0.3
Citadel Advisors LLC	[2020-09-30]	DFND	0.3	0.3
Invesco Ltd.	[2020-09-30]	DFND	0.0	0.3
State Street Corp	[2020-09-30]	DFND	0.2	0.2
Geode Capital Management LLC	[2020-09-30]	DFND	0.2	0.2
Two Sigma Advisers LLC	[2020-09-30]	SOLE	0.1	0.2
Assenagon Asset Management S.A.	[2020-09-30]	SOLE	0.2	0.2
Millennium Management LLC	[2020-09-30]	SOLE	0.2	0.2
Northern Trust Corp	[2020-09-30]	DFND	0.0	0.1
SIO Capital Management LLC	[2020-09-30]	SOLE	0.1	0.1
Arrowstreet Capital Limited Partnership	[2020-09-30]	DFND	0.1	0.1
D. E. Shaw & Co., Inc.	[2020-09-30]	DFND	0.1	0.1
Caption Management LLC	[2020-09-30]	SOLE	0.1	0.1
Voloridge Investment Management LLC	[2020-09-30]	SOLE	0.1	0.1
Schwab Charles Investment Management Inc	[2020-09-30]	SOLE	0.1	0.1
Engineers Gate Manager LP	[2020-09-30]	SOLE	0.1	0.1
Goldman Sachs Group Inc	[2020-09-30]	DFND	0.1	0.1
Sabby Management LLC	[2020-09-30]	DFND	0.0	0.1
Jacobs Levy Equity Management Inc	[2020-09-30]	SOLE	0.1	0.1
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