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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Nextech Invest Ltd	[2025-06-30]	SOLE	7,162,637	7,162,637
VR Adviser LLC	[2025-06-30]	SOLE	6,596,885	6,596,885
Viking Global Investors LP	[2025-06-30]	SOLE	6,572,700	6,572,700
Pfizer Inc	[2025-06-30]	SOLE	5,376,344	5,376,344
SR One Capital Management LP	[2025-06-30]	SOLE	4,514,929	4,514,929
NEA Management Company LLC	[2025-06-30]	DFND	4,118,621	4,118,621
BlackRock, Inc.	[2025-06-30]	SOLE	3,914,221	4,077,985
Alkeon Capital Management LLC	[2025-06-30]	SOLE	3,751,818	3,751,818
Column Group LLC	[2025-06-30]	SOLE	3,540,777	3,540,777
Vivo Capital LLC	[2025-06-30]	SOLE	3,126,604	3,126,604
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,083,487
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,850,641
FMR LLC	[2025-06-30]	DFND	2,468,708	2,470,057
First TURN Management LLC	[2025-06-30]	SOLE	2,009,923	2,009,923
SilverArc Capital Management LLC	[2025-06-30]	SOLE	1,800,829	1,800,829
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,777,744	1,777,744
MPM BioImpact LLC	[2025-06-30]	SOLE	1,729,378	1,729,378
State Street Corp	[2025-06-30]	DFND	1,573,955	1,632,116
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,618,068	1,618,068
Citadel Advisors LLC	[2025-06-30]	DFND	1,424,668	1,424,668
JPMorgan Chase & Co	[2025-06-30]	DFND	1,179,937	1,335,448
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	1,278,454	1,278,454
Integral Health Asset Management LLC	[2025-06-30]	SOLE	1,250,000	1,250,000
Geode Capital Management LLC	[2025-06-30]	DFND	1,108,460	1,108,460
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	1,065,334	1,065,334
Franklin Resources Inc	[2025-06-30]	DFND	1,042,558	1,042,558
Siren, L.L.C.	[2025-06-30]	DFND	1,007,575	1,007,575
Caption Management LLC	[2025-06-30]	SOLE	996,200	996,200
Euclidean Capital LLC	[2025-06-30]	SOLE	989,410	989,410
Eventide Asset Management LLC	[2025-06-30]	SOLE	951,433	951,433
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