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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	3,315,238.0	3,315,238.0
Foresite Capital Management IV, LLC	[2023-03-31]	SOLE	3,246,926.0	3,246,926.0
Viking Global Investors LP	[2023-03-31]	SOLE	3,231,923.0	3,231,923.0
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	3,180,601.0	3,180,601.0
General Atlantic LP	[2023-03-31]	SOLE	2,420,155.0	2,420,155.0
venBio Partners LLC	[2023-03-31]	SOLE	2,278,575.0	2,278,575.0
Novo Holdings A/S	[2023-03-31]	SOLE	1,329,325.0	1,329,325.0
Cormorant Asset Management LP	[2023-03-31]	DFND	816,460.0	816,460.0
5AM Venture Management LLC	[2023-03-31]	SOLE	587,600.0	587,600.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	559,387.0	559,387.0
Soleus Capital Management LP	[2023-03-31]	SOLE	336,900.0	336,900.0
SIO Capital Management LLC	[2023-03-31]	SOLE	228,385.0	228,385.0
Walleye Capital LLC	[2023-03-31]	SOLE	109,945.0	109,945.0
Morgan Stanley	[2023-03-31]	DFND	23,795.0	48,985.0
Foresite Capital Management V, LLC	[2023-03-31]	SOLE	34,142.0	34,142.0
Lynx1 Capital Management LP	[2023-03-31]	OTR	0.0	26,225.0
Geode Capital Management LLC	[2023-03-31]	DFND	18,643.0	18,643.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	11,500.0	11,500.0
UBS Group AG	[2023-03-31]	SOLE	422.0	422.0
BlackRock Inc.	[2023-03-31]	SOLE	156.0	156.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	1.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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