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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Privium Fund Management B.V.	[2023-03-31]	SOLE	5,344,446.0	5,344,446.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	3,625,467.0	3,625,467.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	2,902,715.0	2,902,715.0
M28 Capital Management LP	[2023-03-31]	SOLE	1,910,600.0	1,910,600.0
Millennium Management LLC	[2023-03-31]	SOLE	1,310,406.0	1,310,406.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	940,582.0	940,582.0
Opaleye Management Inc	[2023-03-31]	SOLE	653,000.0	653,000.0
Morgan Stanley	[2023-03-31]	DFND	628,810.0	648,858.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	626,926.0
Macquarie Group Ltd	[2023-03-31]	SOLE	620,000.0	620,000.0
Ikarian Capital LLC	[2023-03-31]	SOLE	472,625.0	472,625.0
Two Sigma Investments LP	[2023-03-31]	SOLE	417,927.0	417,927.0
Deutsche Bank AG	[2023-03-31]	DFND	0.0	385,208.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	345,300.0	374,000.0
Susquehanna International Group LLP	[2023-03-31]	DFND	0.0	278,400.0
JPMorgan Chase & Co	[2023-03-31]	DFND	222,576.0	222,576.0
Citadel Advisors LLC	[2023-03-31]	DFND	217,779.0	217,779.0
UBS OConnor LLC	[2023-03-31]	DFND	180,000.0	180,000.0
Monaco Asset Management SAM	[2023-03-31]	SOLE	179,334.0	179,334.0
HRT Financial LP	[2023-03-31]	DFND	171,306.0	171,306.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	152,931.0
Franklin Street Advisors Inc /NC	[2023-03-31]	DFND	150,000.0	150,000.0
Cubist Systematic Strategies, LLC	[2023-03-31]	DFND	0.0	101,003.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	95,745.0
Virtu Financial LLC	[2023-03-31]	DFND	94,564.0	94,564.0
Occudo Quantitative Strategies LP	[2023-03-31]	SOLE	88,617.0	88,617.0
Simplex Trading LLC	[2023-03-31]	SOLE	86,152.0	86,152.0
Verition Fund Management LLC	[2023-03-31]	SOLE	63,847.0	63,847.0
Jane Street Group LLC	[2023-03-31]	DFND	55,868.0	55,868.0
Geode Capital Management LLC	[2023-03-31]	DFND	36,293.0	36,293.0
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