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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	6,601,938	6,601,938
Privium Fund Management B.V.	[2025-06-30]	SOLE	4,997,562	4,997,562
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	3,499,512	3,499,512
Morgan Stanley	[2025-06-30]	DFND	3,064,056	3,083,490
SIO Capital Management LLC	[2025-06-30]	SOLE	2,075,139	2,075,139
Aberdeen Group plc	[2025-06-30]	DFND	1,850,348	1,850,348
Kynam Capital Management LP	[2025-06-30]	SOLE	1,649,462	1,649,462
DAFNA Capital Management LLC	[2025-06-30]	SOLE	1,567,561	1,567,561
Siren, L.L.C.	[2025-06-30]	DFND	1,552,183	1,552,183
Woodline Partners LP	[2025-06-30]	SOLE	1,504,000	1,504,000
Platinum Investment Management Ltd	[2025-06-30]	SOLE	1,450,969	1,450,969
Millennium Management LLC	[2025-06-30]	SOLE	1,307,533	1,307,533
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	1,199,638	1,199,638
UBS Group AG	[2025-06-30]	DFND	1,143,835	1,143,835
M28 Capital Management LP	[2025-06-30]	SOLE	1,019,498	1,019,498
Ikarian Capital LLC	[2025-06-30]	SOLE	868,069	868,069
Point72 Asset Management LP	[2025-06-30]	DFND	0	750,000
Macquarie Group Ltd	[2025-06-30]	SOLE	620,000	620,000
Walleye Capital LLC	[2025-06-30]	SOLE	531,977	531,977
Monaco Asset Management SAM	[2025-06-30]	SOLE	460,000	460,000
Northern Trust Corp	[2025-06-30]	DFND	394,779	394,779
Citadel Advisors LLC	[2025-06-30]	DFND	379,263	379,263
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	224,130
Two Sigma Investments LP	[2025-06-30]	SOLE	224,040	224,040
Diadema Partners LP	[2025-06-30]	SOLE	157,694	157,694
Franklin Street Advisors Inc /NC	[2025-06-30]	DFND	150,000	150,000
Two Sigma Advisers LP	[2025-06-30]	SOLE	132,500	140,300
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	121,494
Bank of America Corp /DE/	[2025-06-30]	DFND	0	119,198
Royal Bank of Canada	[2025-06-30]	DFND	112,400	112,400
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