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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2025-06-30]	SOLE	0	10,053,003
BlackRock, Inc.	[2025-06-30]	SOLE	5,922,352	6,256,145
Sands Capital Management LLC	[2025-06-30]	SOLE	2,703,682	3,943,485
JPMorgan Chase & Co	[2025-06-30]	DFND	3,068,394	3,260,506
Baker Bros Advisors LP	[2025-06-30]	SOLE	2,772,692	2,772,692
FMR LLC	[2025-06-30]	DFND	2,586,131	2,604,588
State Street Corp	[2025-06-30]	DFND	2,335,641	2,572,240
Suvretta Capital Management LLC	[2025-06-30]	SOLE	2,278,000	2,278,000
Clearbridge Investments LLC	[2025-06-30]	SOLE	2,104,599	2,140,577
Federated Hermes Inc	[2025-06-30]	DFND	2,049,501	2,049,501
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,871,820
Geode Capital Management LLC	[2025-06-30]	DFND	1,712,931	1,712,931
Caption Management LLC	[2025-06-30]	SOLE	1,707,500	1,707,500
RTW Investments LP	[2025-06-30]	SOLE	1,707,402	1,707,402
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,591,007	1,699,944
Deutsche Bank AG	[2025-06-30]	DFND	1,564,186	1,665,852
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,529,474	1,529,474
Alyeska Investment Group LP	[2025-06-30]	SOLE	1,429,437	1,429,437
Alkeon Capital Management LLC	[2025-06-30]	SOLE	1,404,450	1,404,450
Rock Springs Capital Management LP	[2025-06-30]	SOLE	1,391,072	1,391,072
Deep Track Capital LP	[2025-06-30]	SOLE	1,350,000	1,350,000
AllianceBernstein LP	[2025-06-30]	DFND	1,166,756	1,255,203
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	1,163,755	1,163,755
Susquehanna International Group LLP	[2025-06-30]	OTR	80,223	1,049,323
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	983,715	983,715
Norges Bank	[2025-06-30]	SOLE	983,638	983,638
Farallon Capital Management LLC	[2025-06-30]	OTR	898,000	898,000
Ikarian Capital LLC	[2025-06-30]	SOLE	863,100	863,100
Two Sigma Advisers LP	[2025-06-30]	SOLE	828,100	860,400
Invesco Ltd.	[2025-06-30]	DFND	0	724,115
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