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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	984,915.0	5,408,235.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	4,578,280.0	4,578,280.0
Redmile Group LLC	[2023-03-31]	SOLE	3,811,988.0	3,811,988.0
BlackRock Inc.	[2023-03-31]	SOLE	3,524,427.0	3,622,104.0
Omega Fund Management LLC	[2023-03-31]	SOLE	3,050,187.0	3,050,187.0
State Street Corp	[2023-03-31]	DFND	2,824,513.0	2,904,354.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,319,780.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	2,143,036.0
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	2,098,300.0	2,098,300.0
Camber Capital Management LP	[2023-03-31]	SOLE	1,250,000.0	1,250,000.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	383,180.0	1,230,141.0
FMR LLC	[2023-03-31]	DFND	1,152,616.0	1,153,454.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,124,612.0	1,124,612.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	959,096.0	1,009,803.0
Emerald Advisers LLC	[2023-03-31]	SOLE	701,995.0	963,041.0
Loomis Sayles & Co L P	[2023-03-31]	DFND	944,529.0	958,666.0
Morgan Stanley	[2023-03-31]	DFND	845,333.0	849,449.0
Geode Capital Management LLC	[2023-03-31]	DFND	827,244.0	827,244.0
Emerald Mutual Fund Advisers Trust	[2023-03-31]	SOLE	803,448.0	803,448.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	686,762.0	686,762.0
Candriam SCA	[2023-03-31]	SOLE	662,875.0	662,875.0
Victory Capital Management Inc	[2023-03-31]	SOLE	650,242.0	650,242.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	646,888.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	644,172.0	644,197.0
Millennium Management LLC	[2023-03-31]	SOLE	587,961.0	587,961.0
Artal Group S.A.	[2023-03-31]	DFND	500,000.0	500,000.0
Northern Trust Corp	[2023-03-31]	DFND	15,013.0	445,646.0
Schroder Investment Management Group	[2023-03-31]	SOLE	424,855.0	424,855.0
Amundi	[2023-03-31]	DFND	402,015.0	402,015.0
Integral Health Asset Management LLC	[2023-03-31]	SOLE	395,000.0	395,000.0
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