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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	1,187,392.0	6,822,453.0
RA Capital Management LP	[2023-03-31]	SOLE	0.0	6,416,998.0
RTW Investments LP	[2023-03-31]	SOLE	6,387,178.0	6,387,178.0
BlackRock Inc.	[2023-03-31]	SOLE	5,459,124.0	5,633,425.0
FMR LLC	[2023-03-31]	DFND	5,408,133.0	5,419,057.0
Cowen and Company LLC	[2023-03-31]	DFND	4,592,966.0	4,592,966.0
State Street Corp	[2023-03-31]	DFND	4,256,250.0	4,377,060.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,385,534.0
Cormorant Asset Management LP	[2023-03-31]	DFND	2,612,115.0	2,612,115.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	2,510,000.0	2,510,000.0
Federated Hermes Inc	[2023-03-31]	DFND	2,363,600.0	2,363,600.0
Artisan Partners Limited Partnership	[2023-03-31]	SOLE	1,499,952.0	1,905,321.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,302,033.0	1,302,033.0
Avidity Partners Management LP	[2023-03-31]	SOLE	1,265,545.0	1,265,545.0
Morgan Stanley	[2023-03-31]	DFND	1,246,863.0	1,252,462.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,096,312.0	1,164,797.0
Boxer Capital, LLC	[2023-03-31]	OTR	1,121,327.0	1,121,327.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	977,140.0	1,013,475.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,004,051.0	1,004,051.0
Casdin Capital LLC	[2023-03-31]	SOLE	850,000.0	850,000.0
Alethea Capital Management LLC	[2023-03-31]	SOLE	849,651.0	849,651.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	751,914.0	751,914.0
5AM Venture Management LLC	[2023-03-31]	SOLE	665,555.0	665,555.0
Northern Trust Corp	[2023-03-31]	DFND	29,571.0	600,513.0
Commodore Capital LP	[2023-03-31]	SOLE	590,705.0	590,705.0
JPMorgan Chase & Co	[2023-03-31]	DFND	382,749.0	546,225.0
Franklin Resources Inc	[2023-03-31]	DFND	529,729.0	529,729.0
Artal Group S.A.	[2023-03-31]	DFND	511,962.0	511,962.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	500,000.0	500,000.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	488,597.0	488,597.0
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