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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	8,434,560.0	8,434,560.0
Kennedy Lewis Management LP	[2023-03-31]	SOLE	4,939,931.0	4,939,931.0
JPMorgan Chase & Co	[2023-03-31]	DFND	1,455,161.0	1,455,161.0
ABG-WTT Global Life Science Capital Partners GP Ltd	[2023-03-31]	SOLE	1,038,296.0	1,038,296.0
BlackRock Inc.	[2023-03-31]	SOLE	1,027,060.0	1,027,060.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	944,340.0	944,340.0
Glenview Capital Management LLC	[2023-03-31]	SOLE	818,288.0	818,288.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	185,473.0	760,438.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	726,024.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	700,000.0	700,000.0
Ally Bridge Group NY LLC	[2023-03-31]	SOLE	699,664.0	699,664.0
Advent International Corp/MA	[2023-03-31]	DFND	577,777.0	577,777.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	138,000.0	138,000.0
Rhenman & Partners Asset Management AB	[2023-03-31]	SOLE	0.0	127,152.0
Geode Capital Management LLC	[2023-03-31]	DFND	96,648.0	96,648.0
TD Asset Management Inc	[2023-03-31]	SOLE	58,496.0	58,496.0
Manufacturers Life Insurance Company the	[2023-03-31]	DFND	53,117.0	53,117.0
Resources Management Corp /CT/ /ADV	[2023-03-31]	SOLE	50,029.0	50,029.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	13,607.0	40,700.0
Millennium Management LLC	[2023-03-31]	SOLE	35,057.0	35,057.0
State Street Corp	[2023-03-31]	DFND	26,074.0	26,074.0
Parkwood LLC	[2023-03-31]	SOLE	24,511.0	24,511.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	21,515.0
Citigroup Inc	[2023-03-31]	DFND	15,661.0	15,661.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	15,000.0	15,000.0
Ergoteles LLC	[2023-03-31]	SOLE	13,624.0	13,624.0
Morgan Stanley	[2023-03-31]	DFND	0.0	10,208.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	3,576.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	3,513.0	3,513.0
Tower Research Capital LLC (TRC)	[2023-03-31]	OTR	1,057.0	1,057.0
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