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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	10,445,322	10,445,322
TPG GP A LLC	[2025-06-30]	DFND	6,744,962	6,744,962
OrbiMed Advisors LLC	[2025-06-30]	SOLE	3,704,959	3,704,959
Atlas Venture Life Science Advisors LLC	[2025-06-30]	SOLE	3,694,020	3,694,020
Viking Global Investors LP	[2025-06-30]	SOLE	3,195,181	3,195,181
Enavate Sciences GP, LLC	[2025-06-30]	SOLE	2,478,030	2,478,030
JPMorgan Chase & Co	[2025-06-30]	DFND	1,978,546	2,221,188
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,216,045	1,216,045
Braidwell LP	[2025-06-30]	SOLE	1,081,855	1,081,855
Deerfield Management Company LP	[2025-06-30]	DFND	970,590	970,590
Aberdeen Group plc	[2025-06-30]	DFND	950,547	950,547
Jennison Associates LLC	[2025-06-30]	DFND	752,800	752,800
BlackRock, Inc.	[2025-06-30]	SOLE	628,776	637,104
Vanguard Group Inc	[2025-06-30]	SOLE	0	615,085
Franklin Resources Inc	[2025-06-30]	DFND	500,023	500,023
Baker Bros Advisors LP	[2025-06-30]	SOLE	400,000	400,000
Soleus Capital Management LP	[2025-06-30]	SOLE	376,000	376,000
Siren, L.L.C.	[2025-06-30]	DFND	325,000	325,000
Geode Capital Management LLC	[2025-06-30]	DFND	289,275	289,275
Ameriprise Financial Inc	[2025-06-30]	DFND	0	236,813
Alyeska Investment Group LP	[2025-06-30]	SOLE	186,222	186,222
SilverArc Capital Management LLC	[2025-06-30]	SOLE	186,015	186,015
Prudential Financial Inc	[2025-06-30]	DFND	134,625	135,185
Citadel Advisors LLC	[2025-06-30]	DFND	129,912	129,912
State Street Corp	[2025-06-30]	DFND	118,768	124,518
Rock Springs Capital Management LP	[2025-06-30]	SOLE	99,429	99,429
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	92,832	92,832
Northern Trust Corp	[2025-06-30]	DFND	90,009	90,009
Driehaus Capital Management LLC	[2025-06-30]	SOLE	83,850	83,850
Woodline Partners LP	[2025-06-30]	SOLE	80,000	80,000
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