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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
AyurMaya Capital Management Company, LP	[2024-06-30]	SOLE	9,334,735.0	9,334,735.0
Citadel Advisors LLC	[2024-06-30]	DFND	7,427,764.0	7,427,764.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	5,176,765.0	5,269,374.0
FMR LLC	[2024-06-30]	DFND	4,713,133.0	4,714,172.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	4,698,237.0
Millennium Management LLC	[2024-06-30]	SOLE	4,642,056.0	4,642,056.0
OrbiMed Advisors LLC	[2024-06-30]	SOLE	4,001,711.0	4,001,711.0
venBio Partners LLC	[2024-06-30]	SOLE	3,852,470.0	3,852,470.0
T. Rowe Price Investment Management, Inc.	[2024-06-30]	SOLE	3,330,004.0	3,352,307.0
Blue Owl Capital Holdings LP	[2024-06-30]	DFND	0.0	2,926,028.0
Tybourne Capital Management HK Ltd	[2024-06-30]	SOLE	2,906,629.0	2,906,629.0
General Atlantic LP	[2024-06-30]	SOLE	2,889,668.0	2,889,668.0
JPMorgan Chase & Co	[2024-06-30]	DFND	2,191,478.0	2,598,303.0
Samsara Biocapital LLC	[2024-06-30]	SOLE	2,523,022.0	2,523,022.0
Artal Group S.A.	[2024-06-30]	DFND	2,020,888.0	2,020,888.0
Woodline Partners LP	[2024-06-30]	SOLE	1,984,810.0	1,984,810.0
Palo Alto Investors LP	[2024-06-30]	SOLE	1,715,180.0	1,715,180.0
Opaleye Management Inc	[2024-06-30]	SOLE	1,580,000.0	1,580,000.0
Jacobs Levy Equity Management Inc	[2024-06-30]	SOLE	1,349,963.0	1,479,856.0
Ikarian Capital LLC	[2024-06-30]	SOLE	6,505,077.0	1,475,074.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	1,400,000.0	1,400,000.0
Geode Capital Management LLC	[2024-06-30]	DFND	1,262,983.0	1,262,983.0
Morgan Stanley	[2024-06-30]	DFND	1,251,783.0	1,252,816.0
State Street Corp	[2024-06-30]	DFND	1,075,802.0	1,157,002.0
RTW Investments LP	[2024-06-30]	SOLE	978,310.0	978,310.0
Kynam Capital Management LP	[2024-06-30]	SOLE	831,310.0	831,310.0
Goldman Sachs Group Inc	[2024-06-30]	DFND	799,407.0	799,632.0
DAFNA Capital Management LLC	[2024-06-30]	SOLE	693,609.0	693,609.0
Marshall Wace LLP	[2024-06-30]	OTR	0.0	603,871.0
Kennedy Capital Management LLC	[2024-06-30]	SOLE	485,541.0	522,259.0
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