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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	33,722,974	33,722,974
FMR LLC	[2025-06-30]	DFND	9,217,461	9,226,376
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,552,104
BlackRock, Inc.	[2025-06-30]	SOLE	6,688,154	6,846,667
State Street Corp	[2025-06-30]	DFND	3,898,299	4,017,697
Geode Capital Management LLC	[2025-06-30]	DFND	2,934,815	2,934,815
Susquehanna International Group LLP	[2025-06-30]	OTR	299,973	2,425,473
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	2,027,039	2,163,873
UBS Group AG	[2025-06-30]	DFND	2,090,908	2,093,958
Squarepoint Ops LLC	[2025-06-30]	DFND	0	1,577,422
Norges Bank	[2025-06-30]	SOLE	1,389,862	1,389,862
Citadel Advisors LLC	[2025-06-30]	DFND	1,359,217	1,359,217
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,291,635	1,291,671
APEIRON CAPITAL Ltd	[2025-06-30]	SOLE	1,200,941	1,200,941
Aberdeen Group plc	[2025-06-30]	DFND	1,139,530	1,139,530
Caption Management LLC	[2025-06-30]	SOLE	1,056,655	1,056,655
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,000,000	1,000,000
Polymer Capital Management (HK) LTD	[2025-06-30]	SOLE	890,029	890,029
Jane Street Group LLC	[2025-06-30]	DFND	562,010	855,610
Fiera Capital Corp	[2025-06-30]	OTR	505,857	759,430
Rock Springs Capital Management LP	[2025-06-30]	SOLE	710,000	710,000
Sofinnova Investments Inc	[2025-06-30]	SOLE	700,000	700,000
Millennium Management LLC	[2025-06-30]	SOLE	556,009	670,009
Morgan Stanley	[2025-06-30]	DFND	552,996	642,001
Bank of America Corp /DE/	[2025-06-30]	DFND	179,486	566,147
Northern Trust Corp	[2025-06-30]	DFND	530,633	531,561
Candriam S.C.A.	[2025-06-30]	SOLE	513,763	513,763
TD Asset Management Inc	[2025-06-30]	SOLE	484,010	484,010
Invesco Ltd.	[2025-06-30]	DFND	0	424,027
Rockland Trust Co	[2025-06-30]	DFND	400,000	400,000
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