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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Novo Holdings A/S	[2023-03-31]	SOLE	6,722,336.0	6,722,336.0
Armistice Capital LLC	[2023-03-31]	SOLE	3,928,000.0	3,928,000.0
Rivervest Venture Management LLC	[2023-03-31]	SOLE	2,936,281.0	2,936,281.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	2,896,518.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	2,728,125.0	2,728,125.0
5AM Venture Management LLC	[2023-03-31]	SOLE	2,364,000.0	2,364,000.0
Omega Fund Management LLC	[2023-03-31]	SOLE	2,161,022.0	2,161,022.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,698,618.0	1,698,618.0
Aisling Capital Management LP	[2023-03-31]	SOLE	1,205,511.0	1,205,511.0
Alyeska Investment Group LP	[2023-03-31]	SOLE	1,000,000.0	1,000,000.0
Verition Fund Management LLC	[2023-03-31]	SOLE	961,899.0	961,899.0
AIGH Capital Management LLC	[2023-03-31]	SOLE	833,376.0	833,376.0
Sands Capital Ventures LLC	[2023-03-31]	SOLE	787,007.0	787,007.0
Millennium Management LLC	[2023-03-31]	SOLE	608,845.0	608,845.0
CVI Holdings, LLC	[2023-03-31]	DFND	472,000.0	472,000.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	312,000.0	312,000.0
Worth Venture Partners LLC	[2023-03-31]	OTR	0.0	270,624.0
AIGH Capital Management LLC	[2023-03-31]	OTR	0.0	270,624.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	244,264.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	182,656.0	182,656.0
Two Sigma Investments LP	[2023-03-31]	SOLE	163,165.0	163,165.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	159,973.0	160,100.0
BlackRock Inc.	[2023-03-31]	SOLE	151,313.0	151,313.0
Royal Bank of Canada	[2023-03-31]	DFND	93,920.0	93,920.0
State Street Corp	[2023-03-31]	DFND	93,100.0	93,100.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	92,077.0	92,077.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	85,000.0	85,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	60,621.0	60,621.0
JPMorgan Chase & Co	[2023-03-31]	DFND	58,179.0	58,179.0
Marquette Asset Management LLC	[2023-03-31]	SOLE	0.0	55,757.0
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