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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ProSight Management LP	[2025-06-30]	SOLE	6,638,935	6,638,935
Redmile Group LLC	[2025-06-30]	SOLE	5,539,724	5,539,724
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	4,675,000	4,675,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,133,317
Clark Estates Inc/Ny	[2025-06-30]	SOLE	1,475,648	1,475,648
Pinnacle Associates Ltd	[2025-06-30]	SOLE	1,363,723	1,363,723
683 Capital Management LLC	[2025-06-30]	DFND	1,095,000	1,095,000
BlackRock, Inc.	[2025-06-30]	SOLE	874,384	881,388
Millennium Management LLC	[2025-06-30]	SOLE	843,256	843,256
Takeda Pharmaceutical Co Ltd	[2025-06-30]	DFND	515,619	515,619
Geode Capital Management LLC	[2025-06-30]	DFND	467,959	467,959
Goldman Sachs Group Inc	[2025-06-30]	DFND	325,254	325,254
Pathstone Holdings, LLC	[2025-06-30]	SOLE	0	314,166
Jane Street Group LLC	[2025-06-30]	DFND	289,671	289,671
UBS Group AG	[2025-06-30]	DFND	268,371	268,371
Acadian Asset Management LLC	[2025-06-30]	DFND	260,958	260,958
Susquehanna International Group LLP	[2025-06-30]	OTR	196,328	196,328
State Street Corp	[2025-06-30]	DFND	176,718	176,718
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	123,172	123,172
Northern Trust Corp	[2025-06-30]	DFND	110,983	110,983
Bank of New York Mellon Corp	[2025-06-30]	DFND	110,394	110,394
Adar1 Capital Management LLC	[2025-06-30]	SOLE	102,948	102,948
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	92,300	92,300
Two Sigma Investments LP	[2025-06-30]	SOLE	76,934	76,934
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	55,380	55,380
EP Wealth Advisors LLC	[2025-06-30]	SOLE	41,167	41,167
Piper Sandler & Co	[2025-06-30]	SOLE	39,467	39,467
Renaissance Technologies LLC	[2025-06-30]	SOLE	38,100	38,100
AQR Capital Management LLC	[2025-06-30]	DFND	37,252	37,252
Bank of America Corp /DE/	[2025-06-30]	DFND	0	36,891
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