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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	6,367,363.0	6,367,363.0
Redmile Group LLC	[2023-03-31]	SOLE	5,619,914.0	5,619,914.0
ProSight Management LP	[2023-03-31]	SOLE	2,021,668.0	2,021,668.0
Clark Estates Inc/Ny	[2023-03-31]	SOLE	1,475,648.0	1,475,648.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,165,559.0
Investment Management of Virginia LLC	[2023-03-31]	SOLE	506,040.0	506,040.0
Laurion Capital Management LP	[2023-03-31]	SOLE	506,000.0	506,000.0
BlackRock Inc.	[2023-03-31]	SOLE	492,550.0	504,670.0
Geode Capital Management LLC	[2023-03-31]	DFND	346,185.0	346,185.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	188,867.0	248,167.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	123,086.0	123,086.0
Pathstone Family Office LLC	[2023-03-31]	SOLE	0.0	115,339.0
Ritholtz Wealth Management	[2023-03-31]	SOLE	0.0	108,615.0
State Street Corp	[2023-03-31]	DFND	92,318.0	92,318.0
Villere St Denis J & Co LLC	[2023-03-31]	SOLE	88,071.0	88,071.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	85,200.0	85,200.0
LBJ Family Wealth Advisors Ltd	[2023-03-31]	SOLE	0.0	82,177.0
Citadel Advisors LLC	[2023-03-31]	DFND	79,004.0	79,004.0
Northern Trust Corp	[2023-03-31]	DFND	4.0	65,690.0
Benjamin F Edwards & Company Inc	[2023-03-31]	DFND	0.0	63,600.0
Millennium Management LLC	[2023-03-31]	SOLE	59,280.0	59,280.0
Cornercap Investment Counsel Inc	[2023-03-31]	SOLE	34,246.0	50,002.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	47,773.0
Cloverfields Capital Group LP	[2023-03-31]	SOLE	45,000.0	45,000.0
State of Wisconsin Investment Board	[2023-03-31]	SOLE	44,800.0	44,800.0
Piper Sandler & Co	[2023-03-31]	SOLE	39,467.0	39,467.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	33,400.0	33,400.0
Dimensional Fund Advisors LP	[2023-03-31]	DFND	0.0	29,663.0
Qube Research & Technologies Ltd	[2023-03-31]	SOLE	0.0	26,479.0
Morgan Stanley	[2023-03-31]	DFND	24,915.0	24,915.0
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