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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vivo Capital LLC	[2025-06-30]	SOLE	5,903,000	5,903,000
OrbiMed Advisors LLC	[2025-06-30]	SOLE	0	2,718,735
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,312,520	1,312,520
Neumann Advisory Hong Kong Ltd	[2025-06-30]	SOLE	315,586	315,586
California Public Employees Retirement System	[2025-06-30]	SOLE	68,732	68,732
Skandinaviska Enskilda Banken AB (publ)	[2025-06-30]	SOLE	40,000	40,000
Spark Investment Management LLC	[2025-06-30]	SOLE	29,100	29,100
Geode Capital Management LLC	[2025-06-30]	DFND	27,717	27,717
Wells Fargo & Company/MN	[2025-06-30]	DFND	12,590	16,851
Susquehanna International Group LLP	[2025-06-30]	OTR	16,430	16,430
Navellier & Associates Inc	[2025-06-30]	SOLE	0	13,159
Morgan Stanley	[2025-06-30]	DFND	5,224	8,344
Bank of America Corp /DE/	[2025-06-30]	DFND	5,000	5,886
Raymond James Financial Inc	[2025-06-30]	DFND	0	2,511
UBS Group AG	[2025-06-30]	DFND	2,213	2,213
Atlantic Edge Private Wealth Management LLC	[2025-06-30]	SOLE	1,000	1,000
Clearstead Advisors LLC	[2025-06-30]	SOLE	0	500
Royal Bank of Canada	[2025-06-30]	DFND	425	425
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	424	424
IFP Advisors, Inc	[2025-06-30]	SOLE	200	200
Horizon Investments LLC	[2025-06-30]	SOLE	0	52
Jones Financial Companies LLLP	[2025-06-30]	SOLE	0	36
AssetMark Inc	[2025-06-30]	SOLE	24	24
Financial Gravity Companies, Inc.	[2025-06-30]	SOLE	23	23
MAI Capital Management	[2025-06-30]	SOLE	0	3
Ameritas Advisory Services LLC	[2025-06-30]	SOLE	0	3
Transamerica Financial Advisors LLC	[2025-06-30]	SOLE	0	2
Osaic Holdings Inc	[2025-06-30]	DFND	0	1
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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