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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	4,865,819	4,865,819
MPM Asset Management LLC	[2025-06-30]	SOLE	4,381,062	4,381,062
5AM Venture Management LLC	[2025-06-30]	SOLE	4,308,379	4,308,379
BlackRock, Inc.	[2025-06-30]	SOLE	1,968,487	2,022,150
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,584,489
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,521,281
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,060,716
StepStone Group LP	[2025-06-30]	DFND	761,277	761,277
Geode Capital Management LLC	[2025-06-30]	DFND	631,554	631,554
TCG Crossover Management LLC	[2025-06-30]	SOLE	584,955	584,955
FMR LLC	[2025-06-30]	DFND	495,677	496,129
State Street Corp	[2025-06-30]	DFND	465,262	495,862
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	378,271	401,979
Renaissance Technologies LLC	[2025-06-30]	SOLE	379,500	379,500
Northern Trust Corp	[2025-06-30]	DFND	296,421	296,421
Royce & Associates LP	[2025-06-30]	SOLE	223,251	223,251
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	188,247	220,736
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	203,693	203,693
Millennium Management LLC	[2025-06-30]	SOLE	170,322	170,322
Morgan Stanley	[2025-06-30]	DFND	155,326	163,097
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	133,730	133,730
Moore Capital Management LP	[2025-06-30]	SOLE	105,000	105,000
Arrowstreet Capital Limited Partnership	[2025-06-30]	DFND	102,008	102,008
Citadel Advisors LLC	[2025-06-30]	DFND	100,357	100,357
Bank of New York Mellon Corp	[2025-06-30]	DFND	91,026	98,028
Federated Hermes Inc	[2025-06-30]	DFND	96,686	96,686
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	87,387	87,387
Goldman Sachs Group Inc	[2025-06-30]	DFND	84,150	84,150
First Trust Advisors LP	[2025-06-30]	SOLE	75,120	75,120
American Century Companies Inc	[2025-06-30]	DFND	75,094	75,094
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