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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2023-03-31]	SOLE	4,865,819.0	4,865,819.0
MPM Asset Management LLC	[2023-03-31]	SOLE	4,425,784.0	4,425,784.0
5AM Venture Management LLC	[2023-03-31]	SOLE	4,408,379.0	4,408,379.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	487,552.0	2,983,863.0
Redmile Group LLC	[2023-03-31]	SOLE	1,831,608.0	1,831,608.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	1,014,453.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	913,625.0
StepStone Group LP	[2023-03-31]	DFND	761,277.0	761,277.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	584,955.0	584,955.0
FMR LLC	[2023-03-31]	DFND	531,385.0	531,408.0
72 Investment Holdings, LLC	[2023-03-31]	DFND	0.0	509,023.0
BlackRock Inc.	[2023-03-31]	SOLE	208,528.0	211,985.0
Laurion Capital Management LP	[2023-03-31]	SOLE	199,066.0	199,066.0
Millennium Management LLC	[2023-03-31]	SOLE	197,253.0	197,253.0
Susquehanna International Group LLP	[2023-03-31]	DFND	196,513.0	196,513.0
Geode Capital Management LLC	[2023-03-31]	DFND	183,790.0	183,790.0
Moore Capital Management LP	[2023-03-31]	SOLE	105,000.0	105,000.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	89,478.0	89,478.0
Jane Street Group LLC	[2023-03-31]	DFND	73,898.0	73,898.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	73,582.0	73,582.0
State Street Corp	[2023-03-31]	DFND	64,577.0	64,577.0
Citigroup Inc	[2023-03-31]	DFND	62,023.0	62,023.0
TD Asset Management Inc	[2023-03-31]	SOLE	59,627.0	59,627.0
CHI Advisors LLC	[2023-03-31]	DFND	56,374.0	56,374.0
Manufacturers Life Insurance Company the	[2023-03-31]	DFND	47,712.0	47,712.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	47,176.0	47,176.0
Morgan Stanley	[2023-03-31]	DFND	30,754.0	41,768.0
Qube Research & Technologies Ltd	[2023-03-31]	SOLE	0.0	38,782.0
HRT Financial LP	[2023-03-31]	DFND	38,395.0	38,395.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	33,771.0
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