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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
NEA Management Company LLC	[2025-06-30]	DFND	13,222,228	13,222,228
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	10,259,409	10,259,409
Rubric Capital Management LP	[2025-06-30]	SOLE	8,531,860	8,531,860
BlackRock, Inc.	[2025-06-30]	SOLE	7,700,471	8,205,006
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,196,465
Vivo Capital LLC	[2025-06-30]	SOLE	4,487,903	4,487,903
AllianceBernstein LP	[2025-06-30]	DFND	4,154,966	4,281,355
Woodline Partners LP	[2025-06-30]	SOLE	4,046,435	4,046,435
Siren, L.L.C.	[2025-06-30]	DFND	3,938,793	3,938,793
Octagon Capital Advisors LP	[2025-06-30]	SOLE	3,672,000	3,672,000
MPM BioImpact LLC	[2025-06-30]	SOLE	3,406,955	3,406,955
OrbiMed Advisors LLC	[2025-06-30]	DFND	1,079,400	3,308,400
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	2,534,058	2,534,058
Marshall Wace LLP	[2025-06-30]	OTR	0	2,477,916
Balyasny Asset Management LP	[2025-06-30]	SOLE	2,354,402	2,354,402
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	2,144,844	2,144,844
State Street Corp	[2025-06-30]	DFND	1,729,518	1,832,920
Geode Capital Management LLC	[2025-06-30]	DFND	1,786,845	1,786,845
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,728,676
Citadel Advisors LLC	[2025-06-30]	DFND	1,603,266	1,603,266
Viking Global Investors LP	[2025-06-30]	SOLE	1,543,000	1,543,000
Eventide Asset Management LLC	[2025-06-30]	SOLE	1,381,324	1,381,324
Artia Global Partners LP	[2025-06-30]	SOLE	1,311,840	1,311,840
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	1,146,110
Bank of America Corp /DE/	[2025-06-30]	DFND	13,681	1,097,497
Raymond James Financial Inc	[2025-06-30]	DFND	17,837	1,076,683
Morgan Stanley	[2025-06-30]	DFND	935,662	1,024,011
J Goldman & Co LP	[2025-06-30]	SOLE	979,098	979,098
Logos Global Management LP	[2025-06-30]	SOLE	850,000	850,000
MAI Capital Management	[2025-06-30]	SOLE	404,470	847,553
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