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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Kynam Capital Management LP	[2023-03-31]	SOLE	3,738,972.0	3,738,972.0
BlackRock Inc.	[2023-03-31]	SOLE	3,072,417.0	3,160,523.0
State Street Corp	[2023-03-31]	DFND	3,095,220.0	3,147,389.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,836,820.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	2,769,442.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	2,497,526.0	2,497,526.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,394,186.0	2,394,186.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	667,300.0	2,391,628.0
Casdin Capital LLC	[2023-03-31]	SOLE	2,023,913.0	2,023,913.0
Millennium Management LLC	[2023-03-31]	SOLE	1,942,618.0	1,942,618.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,739,162.0	1,747,522.0
JPMorgan Chase & Co	[2023-03-31]	DFND	1,361,465.0	1,583,681.0
Newtyn Management LLC	[2023-03-31]	SOLE	1,505,000.0	1,505,000.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	1,436,398.0	1,436,398.0
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	1,408,901.0	1,408,901.0
Morgan Stanley	[2023-03-31]	DFND	1,112,691.0	1,165,326.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	1,029,040.0	1,029,040.0
Credit Suisse AG	[2023-03-31]	DFND	1,007,545.0	1,017,974.0
Iron Triangle Partners LP	[2023-03-31]	SOLE	868,939.0	868,939.0
CHI Advisors LLC	[2023-03-31]	DFND	855,000.0	855,000.0
Artal Group S.A.	[2023-03-31]	DFND	750,000.0	750,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	741,472.0	741,472.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	119,448.0	590,089.0
Sectoral Asset Management Inc	[2023-03-31]	SOLE	214,919.0	476,000.0
Boxer Capital, LLC	[2023-03-31]	OTR	459,836.0	459,836.0
Bank of America Corp /DE/	[2023-03-31]	DFND	9,522.0	399,936.0
Barclays PLC	[2023-03-31]	SOLE	394,126.0	394,126.0
Deep Track Capital LP	[2023-03-31]	SOLE	350,000.0	350,000.0
Northern Trust Corp	[2023-03-31]	DFND	16,466.0	348,916.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	319,993.0	319,993.0
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