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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Caligan Partners LP	[2025-06-30]	SOLE	9,239,119	9,239,119
Armistice Capital LLC	[2025-06-30]	SOLE	8,881,344	8,881,344
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,159,688
Millennium Management LLC	[2025-06-30]	SOLE	907,076	907,076
Sovran Advisors LLC	[2025-06-30]	SOLE	0	750,391
Geode Capital Management LLC	[2025-06-30]	DFND	646,156	646,156
Mariner LLC	[2025-06-30]	SOLE	0	245,666
Northern Trust Corp	[2025-06-30]	DFND	207,402	207,402
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	186,955	186,955
Goldman Sachs Group Inc	[2025-06-30]	DFND	175,284	175,284
BML Capital Management LLC	[2025-06-30]	SOLE	0	174,651
State Street Corp	[2025-06-30]	DFND	91,816	91,816
Two Sigma Investments LP	[2025-06-30]	SOLE	87,293	87,293
Renaissance Technologies LLC	[2025-06-30]	SOLE	87,200	87,200
Steelpeak Wealth LLC	[2025-06-30]	SOLE	0	76,000
UBS Group AG	[2025-06-30]	DFND	72,411	72,730
Citadel Advisors LLC	[2025-06-30]	DFND	68,660	68,660
Susquehanna International Group LLP	[2025-06-30]	OTR	66,585	66,585
Miracle Mile Advisors, LLC	[2025-06-30]	SOLE	0	59,769
BlackRock, Inc.	[2025-06-30]	SOLE	52,409	56,470
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	52,955	52,955
AQR Capital Management LLC	[2025-06-30]	DFND	49,207	49,207
FMR LLC	[2025-06-30]	DFND	7,971	39,136
Jane Street Group LLC	[2025-06-30]	DFND	38,330	38,330
SPC Financial Inc	[2025-06-30]	SOLE	0	30,000
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	26,886	26,886
Morgan Stanley	[2025-06-30]	DFND	9,378	26,266
Capital Analysts LLC	[2025-06-30]	DFND	0	21,300
Dynamic Technology Lab Private Ltd	[2025-06-30]	SOLE	20,300	20,300
Mariner LLC	[2025-06-30]	OTR	0	19,629
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