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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Stonepine Capital Management LLC	[2023-03-31]	SOLE	8,640,205.0	8,640,205.0
BlackRock Inc.	[2023-03-31]	SOLE	8,333,957.0	8,413,180.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	6,593,163.0
Caxton Corp	[2023-03-31]	SOLE	6,039,028.0	6,039,028.0
Geode Capital Management LLC	[2023-03-31]	DFND	2,530,705.0	2,530,705.0
State Street Corp	[2023-03-31]	DFND	2,144,471.0	2,283,571.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	2,102,337.0
Northern Trust Corp	[2023-03-31]	DFND	28,324.0	1,109,577.0
Redmile Group LLC	[2023-03-31]	SOLE	1,046,587.0	1,046,587.0
Tudor Investment Corp ET AL	[2023-03-31]	DFND	1,565.0	960,111.0
JPMorgan Chase & Co	[2023-03-31]	DFND	664,867.0	766,291.0
Deltec Asset Management LLC	[2023-03-31]	SOLE	622,072.0	622,072.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	603,894.0	603,894.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	569,247.0
Rubric Capital Management LP	[2023-03-31]	SOLE	426,267.0	426,267.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	421,416.0	421,416.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	393,027.0	411,194.0
Alpine Global Management, LLC	[2023-03-31]	SOLE	400,000.0	400,000.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	374,991.0	374,991.0
GSA Capital Partners LLP	[2023-03-31]	SOLE	316,025.0	316,025.0
Lazard Asset Management LLC	[2023-03-31]	SOLE	282,455.0	289,450.0
IHT Wealth Management LLC	[2023-03-31]	SOLE	3,025.0	281,442.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	264,451.0	264,451.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	247,921.0
Brown Advisory Inc	[2023-03-31]	DFND	236,405.0	236,405.0
XTX Topco Ltd	[2023-03-31]	DFND	233,385.0	233,385.0
Susquehanna International Group LLP	[2023-03-31]	DFND	133,393.0	180,593.0
RhumbLine Advisers	[2023-03-31]	SOLE	67,193.0	172,851.0
Citadel Advisors LLC	[2023-03-31]	DFND	170,900.0	170,900.0
Diversified Trust Co	[2023-03-31]	SOLE	0.0	155,650.0
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