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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	2,590,303
Morgan Stanley	[2025-06-30]	DFND	1,539,397	1,544,967
FMR LLC	[2025-06-30]	DFND	1,076,547	1,079,588
Vanguard Group Inc	[2025-06-30]	SOLE	0	628,533
BlackRock, Inc.	[2025-06-30]	SOLE	581,667	591,673
Opaleye Management Inc	[2025-06-30]	SOLE	255,087	255,087
Geode Capital Management LLC	[2025-06-30]	DFND	203,601	203,601
Woodline Partners LP	[2025-06-30]	SOLE	180,230	180,230
State Street Corp	[2025-06-30]	DFND	142,132	153,483
Stonepine Capital Management LLC	[2025-06-30]	SOLE	152,143	152,143
	[2025-06-30]	SOLE	114,548	114,548
Northern Trust Corp	[2025-06-30]	DFND	92,462	92,462
CM Management LLC	[2025-06-30]	SOLE	64,000	64,000
Bank of New York Mellon Corp	[2025-06-30]	DFND	58,563	59,790
RBF Capital, LLC	[2025-06-30]	SOLE	30,616	30,616
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	26,375	26,375
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	26,200	26,200
Occudo Quantitative Strategies LP	[2025-06-30]	SOLE	20,925	20,925
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	18,563	20,397
PanAgora Asset Management Inc	[2025-06-30]	SOLE	15,214	18,379
Barclays PLC	[2025-06-30]	SOLE	16,640	16,640
Marshall Wace LLP	[2025-06-30]	OTR	0	16,308
UBS Group AG	[2025-06-30]	DFND	16,110	16,110
Los Angeles Capital Management LLC	[2025-06-30]	SOLE	11,415	14,676
RhumbLine Advisers	[2025-06-30]	SOLE	3,388	13,249
Nuveen, LLC	[2025-06-30]	DFND	12,706	12,706
Renaissance Technologies LLC	[2025-06-30]	SOLE	11,900	11,900
Susquehanna International Group LLP	[2025-06-30]	OTR	11,559	11,559
Vanguard Group Inc	[2025-06-30]	DFND	0	10,280
Deutsche Bank AG	[2025-06-30]	DFND	112	8,476
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