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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
SR One Capital Management LP	[2025-06-30]	SOLE	4,911,539	4,911,539
Enavate Sciences GP, LLC	[2025-06-30]	SOLE	3,761,359	3,761,359
FMR LLC	[2025-06-30]	DFND	3,322,656	3,323,534
NEA Management Company LLC	[2025-06-30]	DFND	2,733,719	2,733,719
Novo Holdings A/S	[2025-06-30]	SOLE	2,250,000	2,250,000
Fairmount Funds Management LLC	[2025-06-30]	SOLE	1,892,806	1,892,806
Federated Hermes Inc	[2025-06-30]	DFND	1,861,838	1,861,838
NVP Associates, LLC	[2025-06-30]	SOLE	1,838,482	1,838,482
Deerfield Management Company LP	[2025-06-30]	DFND	1,562,942	1,562,942
Vivo Capital LLC	[2025-06-30]	SOLE	1,183,260	1,183,260
BlackRock, Inc.	[2025-06-30]	SOLE	1,065,720	1,095,609
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	1,094,338	1,094,338
Vanguard Group Inc	[2025-06-30]	SOLE	0	980,325
Wellington Management Group LLP	[2025-06-30]	DFND	0	878,918
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	779,045
Rock Springs Capital Management LP	[2025-06-30]	SOLE	640,467	640,467
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	432,709	447,849
Geode Capital Management LLC	[2025-06-30]	DFND	373,617	373,617
Eversept Partners LP	[2025-06-30]	SOLE	325,479	325,479
State Street Corp	[2025-06-30]	DFND	292,136	310,236
Citadel Advisors LLC	[2025-06-30]	DFND	293,785	293,785
Catalio Capital Management LP	[2025-06-30]	SOLE	215,314	215,314
Sectoral Asset Management Inc	[2025-06-30]	SOLE	0	210,625
Schroder Investment Management Group	[2025-06-30]	SOLE	154,916	154,916
Morgan Stanley	[2025-06-30]	DFND	90,961	124,301
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	122,210	122,210
Northern Trust Corp	[2025-06-30]	DFND	116,886	117,079
Superstring Capital Management LP	[2025-06-30]	SOLE	111,605	111,605
Bank of New York Mellon Corp	[2025-06-30]	DFND	33,724	38,433
Price T Rowe Associates Inc /MD/	[2025-06-30]	DFND	37,353	37,353
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