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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	27,525,640	27,525,640
Capital World Investors	[2025-06-30]	DFND	13,361,096	13,361,096
Baillie Gifford & Co	[2025-06-30]	DFND	7,519,311	8,715,008
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	OTR	0	4,996,419
Two Sigma Investments LP	[2025-06-30]	SOLE	4,110,852	4,110,852
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	4,105,095	4,105,095
Two Sigma Advisers LP	[2025-06-30]	SOLE	3,878,800	4,070,300
BlackRock, Inc.	[2025-06-30]	SOLE	3,447,157	3,680,794
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	3,475,200	3,475,200
UBS Group AG	[2025-06-30]	DFND	3,447,925	3,447,925
Millennium Management LLC	[2025-06-30]	SOLE	3,397,589	3,397,589
OrbiMed Advisors LLC	[2025-06-30]	SOLE	3,344,568	3,344,568
Renaissance Technologies LLC	[2025-06-30]	SOLE	3,307,429	3,307,429
Citadel Advisors LLC	[2025-06-30]	DFND	3,170,560	3,170,560
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,600,000
Guardian Partners Inc	[2025-06-30]	SOLE	1,786,414	1,786,414
Baillie Gifford & Co	[2025-06-30]	SOLE	0	1,644,996
Susquehanna International Group LLP	[2025-06-30]	OTR	594,288	1,136,688
Morgan Stanley	[2025-06-30]	DFND	802,488	996,927
Novo Holdings A/S	[2025-06-30]	SOLE	652,529	652,529
Norges Bank	[2025-06-30]	SOLE	630,938	630,938
State Street Corp	[2025-06-30]	DFND	613,293	614,293
Intellectus Partners LLC	[2025-06-30]	SOLE	548,133	548,133
Driehaus Capital Management LLC	[2025-06-30]	SOLE	499,922	499,922
Royal Bank of Canada	[2025-06-30]	DFND	54,128	403,916
Geode Capital Management LLC	[2025-06-30]	DFND	363,188	363,188
Skandinaviska Enskilda Banken AB (publ)	[2025-06-30]	DFND	0	340,267
Pier 88 Investment Partners LLC	[2025-06-30]	SOLE	244,180	244,180
GSA Capital Partners LLP	[2025-06-30]	SOLE	238,539	238,539
Bank of America Corp /DE/	[2025-06-30]	DFND	0	224,365
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