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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
TCG Crossover Management LLC	[2025-06-30]	SOLE	6,056,596	6,056,596
Deep Track Capital LP	[2025-06-30]	SOLE	3,480,144	3,480,144
Adar1 Capital Management LLC	[2025-06-30]	SOLE	3,071,340	3,071,340
Cormorant Asset Management LP	[2025-06-30]	DFND	2,130,000	2,130,000
Caligan Partners LP	[2025-06-30]	SOLE	1,674,400	1,674,400
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,482,994	1,482,994
Franklin Resources Inc	[2025-06-30]	DFND	1,371,050	1,371,050
VR Adviser LLC	[2025-06-30]	SOLE	1,345,780	1,345,780
Great Point Partners LLC	[2025-06-30]	SOLE	0	1,291,617
Octagon Capital Advisors LP	[2025-06-30]	SOLE	1,267,000	1,267,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,252,257	1,252,257
Millennium Management LLC	[2025-06-30]	SOLE	1,251,765	1,251,765
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	870,438
Aberdeen Group plc	[2025-06-30]	DFND	710,516	710,516
Saturn V Capital Management LP	[2025-06-30]	SOLE	622,479	622,479
Morgan Stanley	[2025-06-30]	DFND	475,280	475,280
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	455,684	455,684
Kennedy Capital Management LLC	[2025-06-30]	SOLE	241,188	241,188
Woodline Partners LP	[2025-06-30]	SOLE	183,800	183,800
Citigroup Inc	[2025-06-30]	DFND	170,733	170,733
Point72 Asset Management LP	[2025-06-30]	DFND	0	167,887
UBS Group AG	[2025-06-30]	DFND	167,656	167,656
Allostery Investments LP	[2025-06-30]	SOLE	167,350	167,350
Soleus Capital Management LP	[2025-06-30]	SOLE	125,000	125,000
Barclays PLC	[2025-06-30]	SOLE	113,391	113,391
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	100,000	100,000
Paloma Partners Management Co	[2025-06-30]	OTR	0	95,130
Stempoint Capital LP	[2025-06-30]	SOLE	87,748	87,748
J Goldman & Co LP	[2025-06-30]	SOLE	67,500	67,500
	[2025-06-30]	SOLE	51,156	51,156
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