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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	42,896,690	42,896,690
BlackRock, Inc.	[2025-06-30]	SOLE	20,056,579	20,652,416
Vanguard Group Inc	[2025-06-30]	SOLE	0	14,970,181
RTW Investments LP	[2025-06-30]	SOLE	8,995,547	8,995,547
State Street Corp	[2025-06-30]	DFND	5,806,396	6,178,044
Morgan Stanley	[2025-06-30]	DFND	3,904,998	4,111,247
Point72 Asset Management LP	[2025-06-30]	DFND	0	3,172,511
Citadel Advisors LLC	[2025-06-30]	DFND	3,130,896	3,130,896
Geode Capital Management LLC	[2025-06-30]	DFND	3,024,097	3,024,097
Palo Alto Investors LP	[2025-06-30]	SOLE	2,563,209	2,563,209
First Trust Advisors LP	[2025-06-30]	SOLE	2,434,376	2,434,376
Fred Alger Management LLC	[2025-06-30]	SOLE	1,646,777	2,387,456
Rockefeller Capital Management L.P.	[2025-06-30]	DFND	2,328,788	2,328,788
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	2,076,873	2,255,213
Marshall Wace LLP	[2025-06-30]	OTR	0	1,969,711
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	1,858,421	1,964,521
Citigroup Inc	[2025-06-30]	DFND	1,786,640	1,786,640
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	1,711,595	1,711,595
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,605,143	1,648,088
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,464,443	1,584,534
American Century Companies Inc	[2025-06-30]	DFND	1,567,388	1,567,388
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,547,732	1,547,732
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,500,000
Norges Bank	[2025-06-30]	SOLE	1,468,647	1,468,647
Northern Trust Corp	[2025-06-30]	DFND	1,234,526	1,238,248
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,189,769	1,189,861
Bank of America Corp /DE/	[2025-06-30]	DFND	30,129	878,284
Invesco Ltd.	[2025-06-30]	DFND	0	857,980
Nuveen, LLC	[2025-06-30]	DFND	841,683	842,258
Woodline Partners LP	[2025-06-30]	SOLE	837,199	837,199
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