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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2024-06-30]	DFND	6,485,900.0	6,487,334.0
Perceptive Advisors LLC	[2024-06-30]	SOLE	3,889,739.0	3,889,739.0
Paradigm Biocapital Advisors LP	[2024-06-30]	SOLE	3,848,095.0	3,848,095.0
NEA Management Company LLC	[2024-06-30]	DFND	3,745,262.0	3,745,262.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	3,462,522.0	3,516,364.0
SR One Capital Management LP	[2024-06-30]	SOLE	2,346,630.0	2,346,630.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	2,186,879.0
Janus Henderson Group PLC	[2024-06-30]	DFND	0.0	1,902,618.0
State Street Corp	[2024-06-30]	DFND	1,664,852.0	1,755,664.0
Lord Abbett & Co LLC	[2024-06-30]	SOLE	1,471,722.0	1,668,556.0
Price T Rowe Associates Inc /MD/	[2024-06-30]	SOLE	1,585,523.0	1,606,212.0
RA Capital Management LP	[2024-06-30]	SOLE	1,604,014.0	1,604,014.0
Cormorant Asset Management LP	[2024-06-30]	DFND	1,525,000.0	1,525,000.0
Suvretta Capital Management LLC	[2024-06-30]	SOLE	1,516,254.0	1,516,254.0
T. Rowe Price Investment Management, Inc.	[2024-06-30]	SOLE	1,167,918.0	1,173,791.0
Geode Capital Management LLC	[2024-06-30]	DFND	935,186.0	935,186.0
Vestal Point Capital LP	[2024-06-30]	SOLE	675,000.0	675,000.0
Morgan Stanley	[2024-06-30]	DFND	507,314.0	545,077.0
Great Point Partners LLC	[2024-06-30]	DFND	0.0	492,000.0
Affinity Asset Advisors LLC	[2024-06-30]	SOLE	460,000.0	460,000.0
Samsara Biocapital LLC	[2024-06-30]	SOLE	453,641.0	453,641.0
Deutsche Bank AG	[2024-06-30]	DFND	31,878.0	446,530.0
Northern Trust Corp	[2024-06-30]	DFND	6,673.0	350,580.0
BAMCO Inc /NY/	[2024-06-30]	DFND	0.0	342,760.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	323,468.0	323,468.0
Charles Schwab Investment Management Inc	[2024-06-30]	SOLE	313,893.0	313,893.0
PFM Health Sciences LP	[2024-06-30]	DFND	0.0	311,980.0
Bank of America Corp /DE/	[2024-06-30]	DFND	8,484.0	303,406.0
Stempoint Capital LP	[2024-06-30]	SOLE	280,709.0	280,709.0
Integral Health Asset Management LLC	[2024-06-30]	SOLE	275,000.0	275,000.0
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