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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Gilead Sciences Inc	[2025-06-30]	SOLE	6,720,803	6,720,803
FMR LLC	[2025-06-30]	DFND	5,970,458	5,972,151
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	4,649,016	4,649,016
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,857,302
NEA Management Company LLC	[2025-06-30]	DFND	3,745,262	3,745,262
BlackRock, Inc.	[2025-06-30]	SOLE	3,373,561	3,468,184
RA Capital Management LP	[2025-06-30]	SOLE	3,036,527	3,036,527
Vestal Point Capital LP	[2025-06-30]	SOLE	2,750,000	2,750,000
Perceptive Advisors LLC	[2025-06-30]	SOLE	2,478,000	2,478,000
SR One Capital Management LP	[2025-06-30]	SOLE	2,346,630	2,346,630
State Street Corp	[2025-06-30]	DFND	1,469,136	1,592,313
AJU IB Investment Co., Ltd.	[2025-06-30]	SOLE	1,047,557	1,047,557
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,023,582
JPMorgan Chase & Co	[2025-06-30]	DFND	856,439	976,781
Geode Capital Management LLC	[2025-06-30]	DFND	961,778	961,778
Cormorant Asset Management LP	[2025-06-30]	DFND	800,000	800,000
Capital World Investors	[2025-06-30]	DFND	783,011	783,011
Decheng Capital LLC	[2025-06-30]	SOLE	547,609	547,609
Caption Management LLC	[2025-06-30]	SOLE	520,356	520,356
BAMCO Inc /NY/	[2025-06-30]	DFND	0	518,009
Morgan Stanley	[2025-06-30]	DFND	503,688	517,513
Goldman Sachs Group Inc	[2025-06-30]	DFND	510,513	510,605
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	495,000	495,000
American Century Companies Inc	[2025-06-30]	DFND	311,704	431,466
Susquehanna International Group LLP	[2025-06-30]	OTR	62,933	421,133
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	347,708	383,136
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	346,728	346,728
Northern Trust Corp	[2025-06-30]	DFND	340,285	340,285
Deutsche Bank AG	[2025-06-30]	DFND	46,641	329,364
Lord Abbett & Co LLC	[2025-06-30]	SOLE	290,626	326,511
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