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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Knoll Capital Management, LLC	[2025-06-30]	SOLE	5,475,516	5,475,516
Perceptive Advisors LLC	[2025-06-30]	SOLE	4,051,631	4,051,631
BlackRock, Inc.	[2025-06-30]	SOLE	3,782,994	3,852,101
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,436,691
Ardsley Advisory Partners LP	[2025-06-30]	SOLE	2,050,000	2,050,000
AQR Capital Management LLC	[2025-06-30]	DFND	1,339,357	1,413,080
Kingdon Capital Management LLC	[2025-06-30]	DFND	1,331,791	1,331,791
Geode Capital Management LLC	[2025-06-30]	DFND	1,146,597	1,146,597
683 Capital Management LLC	[2025-06-30]	DFND	1,080,000	1,080,000
State Street Corp	[2025-06-30]	DFND	987,216	1,056,585
Morgan Stanley	[2025-06-30]	DFND	507,322	775,036
Kennedy Capital Management LLC	[2025-06-30]	SOLE	684,826	686,968
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	603,627	674,297
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	617,456	634,156
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	487,672	487,672
Northern Trust Corp	[2025-06-30]	DFND	396,075	396,075
Wells Fargo & Company/MN	[2025-06-30]	DFND	29,306	364,169
Susquehanna International Group LLP	[2025-06-30]	OTR	231,766	329,466
Deutsche Bank AG	[2025-06-30]	DFND	268,094	306,775
Woodstock Corp	[2025-06-30]	SOLE	266,756	266,756
PFG Investments LLC	[2025-06-30]	SOLE	0	257,300
Adar1 Capital Management LLC	[2025-06-30]	SOLE	249,920	249,920
Palo Alto Investors LP	[2025-06-30]	SOLE	225,465	225,465
Acadian Asset Management LLC	[2025-06-30]	DFND	192,402	192,402
Walleye Capital LLC	[2025-06-30]	SOLE	167,609	167,609
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	157,538	157,538
IEQ Capital LLC	[2025-06-30]	OTR	15,346	146,854
Savant Capital LLC	[2025-06-30]	SOLE	54,875	144,104
Goldman Sachs Group Inc	[2025-06-30]	DFND	139,614	139,614
Group One Trading LLC	[2025-06-30]	SOLE	132,987	132,987
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