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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Perceptive Advisors LLC	[2023-03-31]	SOLE	11,350,085.0	11,350,085.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,481,474.0
Knoll Capital Management, LLC	[2023-03-31]	SOLE	2,067,160.0	2,067,160.0
Eagle Asset Management Inc	[2023-03-31]	SOLE	1,844,010.0	1,844,010.0
Verition Fund Management LLC	[2023-03-31]	SOLE	1,565,028.0	1,565,028.0
Susquehanna International Group LLP	[2023-03-31]	DFND	1,098,168.0	1,320,468.0
Morgan Stanley	[2023-03-31]	DFND	1,033,052.0	1,179,963.0
Millennium Management LLC	[2023-03-31]	SOLE	1,118,431.0	1,118,431.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	992,407.0	1,045,161.0
BlackRock Inc.	[2023-03-31]	SOLE	977,748.0	984,982.0
Laurion Capital Management LP	[2023-03-31]	SOLE	956,900.0	956,900.0
FMR LLC	[2023-03-31]	DFND	784,496.0	788,789.0
Natixis	[2023-03-31]	SOLE	0.0	674,549.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	645,020.0	645,020.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	470,000.0	527,900.0
Geode Capital Management LLC	[2023-03-31]	DFND	488,345.0	488,345.0
Citadel Advisors LLC	[2023-03-31]	DFND	458,843.0	458,843.0
Johnson & Johnson	[2023-03-31]	DFND	0.0	394,834.0
ProSight Management LP	[2023-03-31]	SOLE	383,447.0	383,447.0
EAM Investors LLC	[2023-03-31]	SOLE	0.0	291,945.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	287,243.0	287,243.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	282,706.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	328.0	271,843.0
Jane Street Group LLC	[2023-03-31]	DFND	269,530.0	269,530.0
Cantor Fitzgerald L P	[2023-03-31]	DFND	0.0	253,000.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	247,400.0	247,400.0
J Goldman & Co LP	[2023-03-31]	SOLE	229,175.0	229,175.0
Deutsche Bank AG	[2023-03-31]	DFND	224,054.0	224,054.0
Two Sigma Investments LP	[2023-03-31]	SOLE	220,500.0	220,500.0
Connor Clark & Lunn Investment Management Ltd	[2023-03-31]	SOLE	183,070.0	183,070.0
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