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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Inc.	[2023-03-31]	SOLE	7,200,597.0	7,583,916.0
FMR LLC	[2023-03-31]	DFND	6,387,005.0	6,387,376.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	6,240,283.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	4,056,548.0	4,056,548.0
State Street Corp	[2023-03-31]	DFND	3,394,674.0	3,565,331.0
Braidwell LP	[2023-03-31]	SOLE	3,206,315.0	3,206,315.0
Federated Hermes Inc	[2023-03-31]	DFND	2,748,153.0	2,748,153.0
JPMorgan Chase & Co	[2023-03-31]	DFND	2,039,592.0	2,381,982.0
Franklin Resources Inc	[2023-03-31]	DFND	1,593,971.0	1,594,310.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,333,342.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,218,724.0	1,218,724.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	1,055,192.0	1,055,192.0
Euclidean Capital LLC	[2023-03-31]	SOLE	980,894.0	980,894.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	964,851.0	964,851.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	649,961.0	649,961.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	213,375.0	635,122.0
Northern Trust Corp	[2023-03-31]	DFND	33,743.0	597,334.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	592,438.0	592,438.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	422,500.0	472,800.0
Bank of America Corp /DE/	[2023-03-31]	DFND	9,157.0	471,853.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	458,947.0	458,947.0
Morgan Stanley	[2023-03-31]	DFND	370,259.0	448,962.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	394,446.0	428,696.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	427,971.0	427,971.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	372,121.0	409,327.0
Baillie Gifford & Co	[2023-03-31]	DFND	390,113.0	390,113.0
Two Sigma Investments LP	[2023-03-31]	SOLE	366,305.0	366,305.0
Pier Capital LLC	[2023-03-31]	SOLE	204,092.0	363,608.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	341,556.0	341,636.0
New Leaf Venture Partners LLC	[2023-03-31]	DFND	339,569.0	339,569.0
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