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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	14,994,466	14,998,889
BlackRock, Inc.	[2025-06-30]	SOLE	7,681,396	7,973,580
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,919,645
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	4,831,120	4,831,120
Merck & Co., Inc.	[2025-06-30]	DFND	0	3,545,719
Eversept Partners LP	[2025-06-30]	SOLE	1,986,072	1,986,072
Geode Capital Management LLC	[2025-06-30]	DFND	1,982,068	1,982,068
Adar1 Capital Management LLC	[2025-06-30]	SOLE	1,723,526	1,723,526
State Street Corp	[2025-06-30]	DFND	1,614,456	1,709,902
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	1,269,486	1,322,882
Euclidean Capital LLC	[2025-06-30]	SOLE	1,307,858	1,307,858
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,254,850	1,254,850
Deerfield Management Company LP	[2025-06-30]	DFND	1,055,192	1,055,192
5AM Venture Management LLC	[2025-06-30]	SOLE	995,841	995,841
Deutsche Bank AG	[2025-06-30]	DFND	1,547	989,747
Vestal Point Capital LP	[2025-06-30]	SOLE	976,992	976,992
DAFNA Capital Management LLC	[2025-06-30]	SOLE	912,928	912,928
Ikarian Capital LLC	[2025-06-30]	SOLE	900,000	900,000
SIO Capital Management LLC	[2025-06-30]	SOLE	845,531	845,531
TD Asset Management Inc	[2025-06-30]	SOLE	651,738	651,738
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	647,653	647,653
Northern Trust Corp	[2025-06-30]	DFND	645,224	645,374
Morgan Stanley	[2025-06-30]	DFND	593,680	606,552
Citadel Advisors LLC	[2025-06-30]	DFND	595,020	595,020
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	534,200	534,200
PanAgora Asset Management Inc	[2025-06-30]	SOLE	183,629	516,680
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	458,863
Millennium Management LLC	[2025-06-30]	SOLE	410,803	410,803
AQR Capital Management LLC	[2025-06-30]	DFND	398,102	398,102
Two Sigma Advisers LP	[2025-06-30]	SOLE	347,300	377,000
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