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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	1,479,911	1,528,286
Caligan Partners LP	[2025-06-30]	SOLE	1,435,130	1,435,130
Trigran Investments Inc	[2025-06-30]	SOLE	1,266,850	1,266,850
Trigran Investments Inc	[2025-06-30]	OTR	0	769,661
Vanguard Group Inc	[2025-06-30]	SOLE	0	766,312
Opaleye Management Inc	[2025-06-30]	SOLE	588,797	588,797
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	571,861	588,656
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	529,503
Renaissance Technologies LLC	[2025-06-30]	SOLE	527,217	527,217
Alta Fundamental Advisers LLC	[2025-06-30]	SOLE	454,944	454,944
Capital Management Corp /VA	[2025-06-30]	SOLE	401,845	408,845
State Street Corp	[2025-06-30]	DFND	309,156	324,361
Geode Capital Management LLC	[2025-06-30]	DFND	321,211	321,211
Stonepine Capital Management LLC	[2025-06-30]	SOLE	190,590	190,590
Millennium Management LLC	[2025-06-30]	SOLE	133,673	133,673
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	133,047	133,047
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	124,079	124,079
Envestnet Asset Management Inc	[2025-06-30]	SOLE	121,387	121,387
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	100,859	119,338
Northern Trust Corp	[2025-06-30]	DFND	112,606	112,606
Morgan Stanley	[2025-06-30]	DFND	102,331	108,382
UBS Group AG	[2025-06-30]	DFND	90,767	91,067
GlobeFlex Capital L P	[2025-06-30]	SOLE	87,600	87,600
Deutsche Bank AG	[2025-06-30]	DFND	0	81,290
Cove Street Capital LLC	[2025-06-30]	SOLE	74,099	74,099
Wellington Management Group LLP	[2025-06-30]	DFND	0	64,872
Diker Management LLC	[2025-06-30]	SOLE	56,839	56,839
Arrowstreet Capital Limited Partnership	[2025-06-30]	DFND	52,994	52,994
AQR Capital Management LLC	[2025-06-30]	DFND	34,034	50,123
Bank of New York Mellon Corp	[2025-06-30]	DFND	37,413	47,031
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