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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Alerce Investment Management LP	[2023-03-31]	SOLE	7,056,024.0	7,056,024.0
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	4,886,616.0	4,886,616.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	3,549,975.0	3,549,975.0
Redmile Group LLC	[2023-03-31]	SOLE	3,503,190.0	3,503,190.0
VR Adviser LLC	[2023-03-31]	SOLE	3,220,050.0	3,220,050.0
Federated Hermes Inc	[2023-03-31]	DFND	3,057,800.0	3,057,800.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,589,917.0	2,589,917.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	1,867,250.0	1,867,250.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,554,019.0
GMT Capital Corp	[2023-03-31]	SOLE	1,408,697.0	1,408,697.0
Millennium Management LLC	[2023-03-31]	SOLE	1,364,343.0	1,364,343.0
Cormorant Asset Management LP	[2023-03-31]	DFND	1,250,000.0	1,250,000.0
Pictet Asset Management Sa	[2023-03-31]	DFND	0.0	1,232,713.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	1,190,000.0	1,190,000.0
BlackRock Inc.	[2023-03-31]	SOLE	1,158,804.0	1,161,116.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	832,672.0	1,090,986.0
Artal Group S.A.	[2023-03-31]	DFND	1,018,303.0	1,018,303.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	1,000,000.0	1,000,000.0
Soleus Capital Management LP	[2023-03-31]	SOLE	915,400.0	915,400.0
Blackstone Inc.	[2023-03-31]	OTR	0.0	910,211.0
Acadian Asset Management LLC	[2023-03-31]	DFND	805,279.0	805,279.0
Massachusetts Financial Services Co /MA/	[2023-03-31]	SOLE	784,030.0	784,030.0
Simplify Asset Management Inc	[2023-03-31]	SOLE	653,483.0	653,483.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	583,913.0	583,913.0
Woodline Partners LP	[2023-03-31]	SOLE	548,474.0	548,474.0
Board of Trustees of The Leland Stanford Junior University	[2023-03-31]	SOLE	482,550.0	482,550.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	464,819.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	461,284.0
Luminus Management LLC	[2023-03-31]	SOLE	425,000.0	425,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	387,083.0	387,083.0
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