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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vestal Point Capital LP	[2025-06-30]	SOLE	11,500,000	11,500,000
Propel Bio Management LLC	[2025-06-30]	DFND	6,797,915	11,285,420
Knoll Capital Management, LLC	[2025-06-30]	SOLE	7,799,687	7,799,687
BlackRock, Inc.	[2025-06-30]	SOLE	5,195,348	5,219,686
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,703,284
Simplify Asset Management Inc	[2025-06-30]	SOLE	4,487,505	4,487,505
Pathstone Holdings, LLC	[2025-06-30]	SOLE	0	2,643,540
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,428,169
Rock Springs Capital Management LP	[2025-06-30]	SOLE	2,075,991	2,075,991
Franklin Resources Inc	[2025-06-30]	DFND	2,003,338	2,003,338
Millennium Management LLC	[2025-06-30]	SOLE	1,944,904	1,944,904
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	1,822,569	1,822,569
Marshall Wace LLP	[2025-06-30]	OTR	0	1,544,191
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,211,629	1,211,629
Geode Capital Management LLC	[2025-06-30]	DFND	968,541	968,541
UBS Group AG	[2025-06-30]	DFND	758,586	830,645
Citadel Advisors LLC	[2025-06-30]	DFND	752,294	752,294
Goldman Sachs Group Inc	[2025-06-30]	DFND	730,718	730,718
Deutsche Bank AG	[2025-06-30]	DFND	0	622,227
Susquehanna International Group LLP	[2025-06-30]	OTR	586,675	612,575
Two Sigma Investments LP	[2025-06-30]	SOLE	594,534	594,534
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	403,514	403,514
State Street Corp	[2025-06-30]	DFND	352,377	352,377
Morgan Stanley	[2025-06-30]	DFND	342,636	342,636
Two Sigma Advisers LP	[2025-06-30]	SOLE	287,700	303,900
Hennion & Walsh Asset Management Inc	[2025-06-30]	SOLE	287,998	287,998
AQR Capital Management LLC	[2025-06-30]	DFND	284,328	284,328
Birchview Capital LP	[2025-06-30]	SOLE	280,000	280,000
Hightower Advisors LLC	[2025-06-30]	SOLE	220,001	220,001
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	196,660	196,660
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