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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bain Capital Life Sciences Investors, LLC	[2023-03-31]	SOLE	8,891,758.0	8,891,758.0
Adams Street Partners LLC	[2023-03-31]	SOLE	5,395,996.0	5,395,996.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,860,971.0
BlackRock Inc.	[2023-03-31]	SOLE	666,007.0	689,982.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	452,226.0	452,226.0
Acadian Asset Management LLC	[2023-03-31]	DFND	379,326.0	379,326.0
Geode Capital Management LLC	[2023-03-31]	DFND	377,582.0	377,582.0
Virtu Financial LLC	[2023-03-31]	DFND	280,430.0	280,430.0
Millennium Management LLC	[2023-03-31]	SOLE	225,101.0	225,101.0
Cetera Advisor Networks LLC	[2023-03-31]	SOLE	0.0	190,000.0
Meridian Wealth Management LLC	[2023-03-31]	SOLE	0.0	180,000.0
State Street Corp	[2023-03-31]	DFND	138,251.0	138,251.0
Northwestern University	[2023-03-31]	SOLE	109,280.0	109,280.0
Morgan Stanley	[2023-03-31]	DFND	98,957.0	104,736.0
Two Sigma Investments LP	[2023-03-31]	SOLE	81,232.0	81,232.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	80,858.0	80,858.0
Northern Trust Corp	[2023-03-31]	DFND	105.0	66,798.0
Two Sigma Securities LLC	[2023-03-31]	SOLE	52,949.0	52,949.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	46,312.0	46,312.0
LPL Financial LLC	[2023-03-31]	SOLE	0.0	40,000.0
Raymond James & Associates	[2023-03-31]	SOLE	0.0	26,675.0
Group One Trading LP	[2023-03-31]	SOLE	20,653.0	20,653.0
Blair William & Co/IL	[2023-03-31]	SOLE	19,877.0	19,877.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	10,100.0	15,000.0
Concord Wealth Partners	[2023-03-31]	SOLE	0.0	10,000.0
Calamos Wealth Management LLC	[2023-03-31]	SOLE	10,000.0	10,000.0
Northern Trust Corp	[2023-03-31]	OTR	0.0	6,825.0
Allworth Financial LP	[2023-03-31]	SOLE	0.0	1,000.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	800.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	272.0	772.0
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