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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Matrix Capital Management Company LP	[2025-06-30]	SOLE	6,922,870	6,922,870
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	5,100,000	5,100,000
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	4,881,125	4,881,125
Long Focus Capital Management LLC	[2025-06-30]	SOLE	4,619,582	4,619,582
Suvretta Capital Management LLC	[2025-06-30]	SOLE	4,372,884	4,372,884
BlackRock, Inc.	[2025-06-30]	SOLE	3,038,703	3,102,524
Medicxi Ventures Management (Jersey) Ltd	[2025-06-30]	SOLE	3,039,892	3,039,892
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,412,640
Franklin Resources Inc	[2025-06-30]	DFND	2,340,810	2,340,810
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,117,697	2,117,697
Levin Capital Strategies LP	[2025-06-30]	OTR	0	1,495,560
Samsara Biocapital LLC	[2025-06-30]	SOLE	1,000,000	1,000,000
Geode Capital Management LLC	[2025-06-30]	DFND	929,974	929,974
UBS Group AG	[2025-06-30]	DFND	891,028	891,028
State Street Corp	[2025-06-30]	DFND	818,346	856,186
Regency Capital Management Inc.\DE	[2025-06-30]	SOLE	1,100	665,881
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	595,744	595,744
B Group, Inc.	[2025-06-30]	SOLE	572,576	572,576
Decheng Capital LLC	[2025-06-30]	SOLE	515,555	515,555
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	464,708	464,708
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	352,743	390,357
Northern Trust Corp	[2025-06-30]	DFND	364,763	364,763
Goldman Sachs Group Inc	[2025-06-30]	DFND	212,298	212,298
Caligan Partners LP	[2025-06-30]	SOLE	200,000	200,000
Wellington Management Group LLP	[2025-06-30]	DFND	0	189,485
Morgan Stanley	[2025-06-30]	DFND	138,311	150,288
Platinum Investment Management Ltd	[2025-06-30]	SOLE	135,402	135,402
Renaissance Technologies LLC	[2025-06-30]	SOLE	131,548	131,548
Millennium Management LLC	[2025-06-30]	SOLE	124,059	124,059
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	119,651	119,651
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