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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	8,259,763	8,668,527
BML Capital Management LLC	[2025-06-30]	SOLE	0	7,609,812
FMR LLC	[2025-06-30]	DFND	5,717,317	5,719,758
Tang Capital Management LLC	[2025-06-30]	OTR	0	4,889,200
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,829,523
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	2,485,638	2,485,638
Geode Capital Management LLC	[2025-06-30]	DFND	1,925,573	1,925,573
State Street Corp	[2025-06-30]	DFND	1,671,801	1,776,401
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,259,402	1,319,801
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,234,100	1,234,100
Two Sigma Advisers LP	[2025-06-30]	SOLE	678,700	700,900
Northern Trust Corp	[2025-06-30]	DFND	663,418	663,660
JPMorgan Chase & Co	[2025-06-30]	DFND	559,806	652,661
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	635,282	635,282
Newtyn Management LLC	[2025-06-30]	SOLE	580,000	580,000
Morgan Stanley	[2025-06-30]	DFND	517,708	544,268
CM Management LLC	[2025-06-30]	SOLE	500,000	500,000
Peapod Lane Capital LLC	[2025-06-30]	SOLE	360,223	452,468
Almitas Capital LLC	[2025-06-30]	SOLE	445,386	445,386
Two Sigma Investments LP	[2025-06-30]	SOLE	366,612	366,612
Wellington Management Group LLP	[2025-06-30]	DFND	0	359,451
Banque Pictet & CIE Sa	[2025-06-30]	SOLE	345,077	345,077
Goldman Sachs Group Inc	[2025-06-30]	DFND	299,657	299,657
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	259,870	290,460
Barclays PLC	[2025-06-30]	SOLE	261,774	261,774
Nuveen, LLC	[2025-06-30]	DFND	255,847	255,847
Bank of New York Mellon Corp	[2025-06-30]	DFND	158,056	200,151
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	194,952	195,852
HSBC Holdings PLC	[2025-06-30]	DFND	195,782	195,782
Auour Investments LLC	[2025-06-30]	SOLE	80,000	177,000
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