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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Viking Global Investors LP	[2025-06-30]	SOLE	18,555,375	18,555,375
Vanguard Group Inc	[2025-06-30]	SOLE	0	16,126,179
BlackRock, Inc.	[2025-06-30]	SOLE	13,790,003	14,258,808
Kohlberg Kravis Roberts & Co LP	[2025-06-30]	OTR	0	13,260,971
Janus Henderson Group PLC	[2025-06-30]	DFND	0	9,276,532
Farallon Capital Management LLC	[2025-06-30]	OTR	7,900,000	7,900,000
UBS Group AG	[2025-06-30]	DFND	6,473,678	6,675,999
Aisling Capital Management LP	[2025-06-30]	SOLE	6,068,125	6,068,125
State Street Corp	[2025-06-30]	DFND	5,432,210	5,896,596
Jane Street Group LLC	[2025-06-30]	DFND	805,942	4,376,942
Susquehanna International Group LLP	[2025-06-30]	OTR	634,573	4,169,073
Capital Research Global Investors	[2025-06-30]	DFND	3,988,298	3,988,298
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	3,800,457	3,800,457
Geode Capital Management LLC	[2025-06-30]	DFND	3,681,580	3,681,580
Invesco Ltd.	[2025-06-30]	DFND	0	2,801,065
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,763,563	2,778,366
AllianceBernstein LP	[2025-06-30]	DFND	2,331,890	2,470,558
Laurion Capital Management LP	[2025-06-30]	SOLE	2,411,248	2,411,248
Two Sigma Investments LP	[2025-06-30]	SOLE	2,339,067	2,339,067
Macquarie Group Ltd	[2025-06-30]	SOLE	2,035,451	2,095,235
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	2,079,002	2,081,253
FMR LLC	[2025-06-30]	DFND	2,017,846	2,027,395
Norges Bank	[2025-06-30]	SOLE	1,956,654	1,956,654
Manufacturers Life Insurance Company the	[2025-06-30]	DFND	1,891,578	1,891,578
SC US TTGP Ltd	[2025-06-30]	DFND	1,860,364	1,860,364
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,647,352	1,807,434
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,743,520	1,743,520
Woodline Partners LP	[2025-06-30]	SOLE	1,704,800	1,704,800
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,393,452	1,691,213
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,630,420	1,684,055
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