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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Eventide Asset Management LLC	[2025-06-30]	SOLE	397,553	4,932,351
Farallon Capital Management LLC	[2025-06-30]	OTR	4,203,920	4,203,920
Wellington Management Group LLP	[2025-06-30]	DFND	0	3,901,599
Soleus Capital Management LP	[2025-06-30]	SOLE	3,820,158	3,820,158
Sands Capital Alternatives, LLC	[2025-06-30]	SOLE	3,570,113	3,570,113
RTW Investments LP	[2025-06-30]	SOLE	3,299,191	3,299,191
Morgan Stanley	[2025-06-30]	DFND	2,945,052	2,949,365
Omega Fund Management LLC	[2025-06-30]	SOLE	1,988,287	1,988,287
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,593,608	1,593,608
Deerfield Management Company LP	[2025-06-30]	DFND	1,168,415	1,168,415
Driehaus Capital Management LLC	[2025-06-30]	SOLE	984,559	1,159,737
Divisadero Street Capital Management LP	[2025-06-30]	SOLE	948,965	948,965
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	925,363	925,363
BlackRock, Inc.	[2025-06-30]	SOLE	845,280	858,359
Holocene Advisors LP	[2025-06-30]	SOLE	770,851	770,851
Vanguard Group Inc	[2025-06-30]	SOLE	0	690,991
Janus Henderson Group PLC	[2025-06-30]	DFND	0	665,653
Marshall Wace LLP	[2025-06-30]	OTR	0	614,965
Vestal Point Capital LP	[2025-06-30]	SOLE	550,000	550,000
Millennium Management LLC	[2025-06-30]	SOLE	542,198	542,198
Citadel Advisors LLC	[2025-06-30]	DFND	539,963	539,963
RA Capital Management LP	[2025-06-30]	SOLE	500,000	500,000
Lord Abbett & Co LLC	[2025-06-30]	SOLE	264,491	419,398
Geode Capital Management LLC	[2025-06-30]	DFND	312,930	312,930
Goldman Sachs Group Inc	[2025-06-30]	DFND	311,001	311,001
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	306,482	306,482
Clearbridge Investments LLC	[2025-06-30]	SOLE	223,902	249,734
Gilder Gagnon Howe & Co LLC	[2025-06-30]	SOLE	0	244,202
State Street Corp	[2025-06-30]	DFND	215,426	229,995
Walleye Capital LLC	[2025-06-30]	SOLE	218,189	218,189
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