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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	6,955,993	6,955,993
Siren, L.L.C.	[2025-06-30]	DFND	5,216,969	5,216,969
Vestal Point Capital LP	[2025-06-30]	SOLE	5,000,000	5,000,000
Red Tree Management LLC	[2025-06-30]	SOLE	3,170,509	3,170,509
TPG GP A LLC	[2025-06-30]	DFND	3,010,425	3,010,425
FMR LLC	[2025-06-30]	DFND	2,538,085	2,538,404
Deep Track Capital LP	[2025-06-30]	SOLE	2,426,657	2,426,657
Omega Fund Management LLC	[2025-06-30]	SOLE	2,204,650	2,204,650
BlackRock, Inc.	[2025-06-30]	SOLE	2,041,974	2,111,320
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,981,307
Blackstone Inc.	[2025-06-30]	OTR	0	1,224,336
FIL Ltd	[2025-06-30]	DFND	1,013,853	1,013,853
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	949,260	949,260
Millennium Management LLC	[2025-06-30]	SOLE	741,019	741,019
Geode Capital Management LLC	[2025-06-30]	DFND	672,485	672,485
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	643,382	643,382
Aisling Capital Management LP	[2025-06-30]	SOLE	568,919	568,919
State Street Corp	[2025-06-30]	DFND	493,306	541,067
Bank of America Corp /DE/	[2025-06-30]	DFND	4,474	451,228
Schroder Investment Management Group	[2025-06-30]	SOLE	425,341	425,341
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	365,581	402,765
Logos Global Management LP	[2025-06-30]	SOLE	400,000	400,000
Woodline Partners LP	[2025-06-30]	SOLE	348,690	348,690
NAN FUNG TRINITY (HK) Ltd	[2025-06-30]	SOLE	342,885	342,885
Rock Springs Capital Management LP	[2025-06-30]	SOLE	336,070	336,070
DAFNA Capital Management LLC	[2025-06-30]	SOLE	317,001	317,001
Napean Trading & Investment Co (Singapore) PTE Ltd	[2025-06-30]	SOLE	275,942	275,942
Readystate Asset Management LP	[2025-06-30]	SOLE	270,200	270,200
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	262,751	262,751
Northern Trust Corp	[2025-06-30]	DFND	226,374	226,374
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