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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Deep Track Capital LP	[2023-03-31]	SOLE	2,819,045.0	2,819,045.0
Jefferies Financial Group Inc.	[2023-03-31]	DFND	1,948,000.0	1,948,000.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	1,816,781.0	1,816,781.0
Morgan Stanley	[2023-03-31]	DFND	1,503,137.0	1,507,749.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	1,474,378.0
Tybourne Capital Management HK Ltd	[2023-03-31]	SOLE	1,408,831.0	1,408,831.0
Candriam SCA	[2023-03-31]	SOLE	1,303,160.0	1,303,160.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	1,009,500.0	1,009,500.0
SIO Capital Management LLC	[2023-03-31]	SOLE	967,347.0	967,347.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	843,814.0	843,814.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	802,400.0
Logos Global Management LP	[2023-03-31]	SOLE	750,000.0	750,000.0
Armistice Capital LLC	[2023-03-31]	SOLE	736,000.0	736,000.0
First Light Asset Management LLC	[2023-03-31]	SOLE	699,328.0	699,328.0
Verition Fund Management LLC	[2023-03-31]	SOLE	582,558.0	582,558.0
BNP Paribas Asset Management Holding S.A.	[2023-03-31]	DFND	0.0	519,573.0
AXA Sa	[2023-03-31]	DFND	460,125.0	460,125.0
Soleus Capital Management LP	[2023-03-31]	SOLE	411,800.0	411,800.0
Ikarian Capital LLC	[2023-03-31]	SOLE	407,112.0	407,112.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	74,634.0	318,076.0
FMR LLC	[2023-03-31]	DFND	287,147.0	287,147.0
Rubric Capital Management LP	[2023-03-31]	SOLE	205,423.0	205,423.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	156,300.0	187,900.0
BlackRock Inc.	[2023-03-31]	SOLE	178,932.0	178,932.0
Two Sigma Investments LP	[2023-03-31]	SOLE	160,576.0	160,576.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	147,799.0	147,799.0
Handelsbanken Fonder AB	[2023-03-31]	SOLE	0.0	131,800.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	122,781.0	122,781.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	122,200.0	122,200.0
Caption Management LLC	[2023-03-31]	SOLE	121,700.0	121,700.0
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