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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	10,885,357	10,885,357
FCPM III Services BV	[2025-06-30]	DFND	0	3,452,330
Armistice Capital LLC	[2025-06-30]	SOLE	2,800,000	2,800,000
Westfield Capital Management Co LP	[2025-06-30]	SOLE	2,238,706	2,780,491
Siren, L.L.C.	[2025-06-30]	DFND	2,012,752	2,012,752
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,772,600
Millennium Management LLC	[2025-06-30]	SOLE	1,443,619	1,443,619
Long Focus Capital Management LLC	[2025-06-30]	SOLE	1,317,293	1,317,293
Deep Track Capital LP	[2025-06-30]	SOLE	1,203,244	1,203,244
Candriam S.C.A.	[2025-06-30]	SOLE	1,172,387	1,172,387
BNP Paribas Asset Management Holding S.A.	[2025-06-30]	DFND	0	1,041,456
Morgan Stanley	[2025-06-30]	DFND	903,713	1,037,153
Tybourne Capital Management HK Ltd	[2025-06-30]	SOLE	993,743	993,743
Bank of America Corp /DE/	[2025-06-30]	DFND	32	830,634
Principal Financial Group Inc	[2025-06-30]	DFND	697,267	697,267
Jefferies Financial Group Inc.	[2025-06-30]	DFND	461,100	461,100
Woodline Partners LP	[2025-06-30]	SOLE	362,325	362,325
Renaissance Technologies LLC	[2025-06-30]	SOLE	318,400	318,400
Platinum Investment Management Ltd	[2025-06-30]	SOLE	285,381	285,381
AXA Sa	[2025-06-30]	DFND	280,152	280,152
Silvercrest Asset Management Group LLC	[2025-06-30]	SOLE	150,395	265,693
BlackRock, Inc.	[2025-06-30]	SOLE	242,201	264,348
Palo Alto Investors LP	[2025-06-30]	SOLE	248,934	248,934
Eversept Partners LP	[2025-06-30]	SOLE	211,469	211,469
Handelsbanken Fonder AB	[2025-06-30]	SOLE	0	200,000
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AM	[2025-06-30]	DFND	193,800	193,800
TD Asset Management Inc	[2025-06-30]	SOLE	193,092	193,092
Legal & General Group Plc	[2025-06-30]	DFND	174,910	174,910
Pinnacle Associates Ltd	[2025-06-30]	SOLE	171,953	171,953
Citadel Advisors LLC	[2025-06-30]	DFND	157,167	157,167
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