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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2023-03-31]	SOLE	8,390,948.0	8,573,429.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	6,217,361.0
FMR LLC	[2023-03-31]	DFND	6,086,604.0	6,087,553.0
BlackRock Inc.	[2023-03-31]	SOLE	5,166,741.0	5,290,311.0
Temasek Holdings (Private) Ltd	[2023-03-31]	DFND	4,094,512.0	4,094,512.0
Farallon Capital Management LLC	[2023-03-31]	OTR	3,431,921.0	3,431,921.0
State Street Corp	[2023-03-31]	DFND	3,099,671.0	3,236,088.0
MWG Management Ltd.	[2023-03-31]	DFND	2,346,934.0	2,346,934.0
Redmile Group LLC	[2023-03-31]	SOLE	1,612,094.0	1,612,094.0
Deep Track Capital LP	[2023-03-31]	SOLE	1,250,000.0	1,250,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,202,329.0	1,202,329.0
SC CHINA HOLDING Ltd	[2023-03-31]	DFND	796,089.0	796,089.0
Morgan Stanley	[2023-03-31]	DFND	666,625.0	730,128.0
JPMorgan Chase & Co	[2023-03-31]	DFND	576,854.0	718,802.0
Bellevue Group AG	[2023-03-31]	DFND	695,421.0	695,421.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	658,566.0	658,566.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	370,244.0	658,566.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	657,516.0	658,258.0
Northern Trust Corp	[2023-03-31]	DFND	37,919.0	607,088.0
Casdin Capital LLC	[2023-03-31]	SOLE	570,000.0	570,000.0
Susquehanna International Group LLP	[2023-03-31]	DFND	181,357.0	521,357.0
Capital Research Global Investors	[2023-03-31]	DFND	491,882.0	491,882.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	434,043.0	468,177.0
Yiheng Capital Management LP	[2023-03-31]	SOLE	463,800.0	463,800.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	463,614.0	463,614.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	459,203.0	459,203.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	387,235.0
Citadel Advisors LLC	[2023-03-31]	DFND	385,300.0	385,300.0
Bank of America Corp /DE/	[2023-03-31]	DFND	9,465.0	377,620.0
Baillie Gifford & Co	[2023-03-31]	DFND	219,797.0	325,956.0
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