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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	12,951,277	12,961,459
Farallon Capital Management LLC	[2025-06-30]	OTR	10,013,111	10,013,111
Vanguard Group Inc	[2025-06-30]	SOLE	0	9,479,306
ARK Investment Management LLC	[2025-06-30]	SOLE	8,366,412	8,847,841
BlackRock, Inc.	[2025-06-30]	SOLE	7,787,192	8,002,689
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	4,729,444	4,729,444
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	4,458,030	4,726,799
Arch Venture Management LLC	[2025-06-30]	SOLE	0	4,540,132
State Street Corp	[2025-06-30]	DFND	3,388,261	3,638,266
Bellevue Group AG	[2025-06-30]	DFND	2,889,288	2,889,288
Citadel Advisors LLC	[2025-06-30]	DFND	2,779,617	2,779,617
Kynam Capital Management LP	[2025-06-30]	SOLE	2,417,647	2,417,647
MWG Management Ltd.	[2025-06-30]	DFND	2,266,934	2,266,934
Geode Capital Management LLC	[2025-06-30]	DFND	2,254,261	2,254,261
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,596,233	1,670,100
Susquehanna International Group LLP	[2025-06-30]	OTR	587,977	1,453,877
Casdin Capital LLC	[2025-06-30]	SOLE	1,450,000	1,450,000
Redmile Group LLC	[2025-06-30]	SOLE	1,423,411	1,423,411
Morgan Stanley	[2025-06-30]	DFND	1,199,025	1,307,156
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,282,490	1,283,123
UBS Group AG	[2025-06-30]	DFND	1,160,730	1,163,894
Voloridge Investment Management LLC	[2025-06-30]	SOLE	1,131,793	1,131,793
Caption Management LLC	[2025-06-30]	SOLE	923,035	923,035
Jane Street Group LLC	[2025-06-30]	DFND	770,710	854,010
Bank of America Corp /DE/	[2025-06-30]	DFND	13,016	851,336
Northern Trust Corp	[2025-06-30]	DFND	813,067	813,254
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	774,851	774,851
Woodline Partners LP	[2025-06-30]	SOLE	761,498	761,498
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	593,815	593,815
JPMorgan Chase & Co	[2025-06-30]	DFND	455,737	580,299
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