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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2023-03-31]	SOLE	11,668,897.0	11,668,897.0
Capital International Investors	[2023-03-31]	DFND	6,545,078.0	6,565,599.0
HHLR Advisors Ltd	[2023-03-31]	OTR	0.0	5,472,259.0
PRIMECAP Management Co/CA/	[2023-03-31]	SOLE	4,935,549.0	5,045,924.0
Temasek Holdings (Private) Ltd	[2023-03-31]	DFND	2,966,463.0	2,966,463.0
Baillie Gifford & Co	[2023-03-31]	DFND	1,398,376.0	2,656,553.0
FMR LLC	[2023-03-31]	DFND	2,481,745.0	2,500,356.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	1,572,341.0
Capital International, Inc./CA/	[2023-03-31]	DFND	913,152.0	997,042.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	126,105.0	774,357.0
BlackRock Inc.	[2023-03-31]	SOLE	705,361.0	705,808.0
Baillie Gifford & Co	[2023-03-31]	SOLE	281,566.0	660,809.0
Artal Group S.A.	[2023-03-31]	DFND	501,335.0	501,335.0
Boxer Capital, LLC	[2023-03-31]	OTR	500,000.0	500,000.0
Public Investment Fund	[2023-03-31]	SOLE	317,685.0	317,685.0
Bank of America Corp /DE/	[2023-03-31]	DFND	2,201.0	310,761.0
State Street Corp	[2023-03-31]	DFND	264,411.0	266,211.0
Capital Group Private Client Services Inc	[2023-03-31]	DFND	244,814.0	246,139.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	239,443.0	239,443.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	184,012.0	184,012.0
Axiom Investors LLC /DE	[2023-03-31]	SOLE	122,273.0	165,676.0
Morgan Stanley	[2023-03-31]	DFND	145,641.0	155,906.0
Capital International SARL	[2023-03-31]	DFND	148,462.0	152,957.0
Zeal Asset Management Ltd	[2023-03-31]	SOLE	0.0	139,904.0
M&G Investment Management Ltd	[2023-03-31]	SOLE	137,642.0	137,642.0
Matthews International Capital Management LLC	[2023-03-31]	SOLE	136,958.0	136,958.0
Bridgewater Associates LP	[2023-03-31]	SOLE	132,117.0	132,117.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	112,940.0
Baird Financial Group, Inc.	[2023-03-31]	DFND	315.0	106,206.0
Mitsubishi UFJ Trust & Banking Corp	[2023-03-31]	SOLE	105,164.0	105,164.0
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