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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Ah Capital Management LLC	[2025-06-30]	SOLE	3,233,170	3,233,170
Sofinnova Investments Inc	[2025-06-30]	SOLE	2,304,901	2,304,901
Cormorant Asset Management LP	[2025-06-30]	DFND	2,140,605	2,140,605
Adar1 Capital Management LLC	[2025-06-30]	SOLE	1,937,123	1,937,123
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,600,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,540,837
BlackRock, Inc.	[2025-06-30]	SOLE	1,249,733	1,287,417
OrbiMed Advisors LLC	[2025-06-30]	SOLE	921,959	921,959
Sands Capital Alternatives, LLC	[2025-06-30]	SOLE	786,353	786,353
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	653,374
Geode Capital Management LLC	[2025-06-30]	DFND	453,455	453,455
Redpoint Management LLC	[2025-06-30]	SOLE	383,254	383,254
Siren, L.L.C.	[2025-06-30]	DFND	382,406	382,406
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	245,592	273,452
Comprehensive Financial Management LLC	[2025-06-30]	SOLE	271,842	271,842
Marshall Wace LLP	[2025-06-30]	OTR	0	226,789
Morgan Stanley	[2025-06-30]	DFND	209,693	213,503
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	200,000
Susquehanna International Group LLP	[2025-06-30]	OTR	43,118	187,518
State Street Corp	[2025-06-30]	DFND	143,749	160,849
Stonepine Capital Management LLC	[2025-06-30]	SOLE	151,085	151,085
Northern Trust Corp	[2025-06-30]	DFND	149,405	149,405
Citadel Advisors LLC	[2025-06-30]	DFND	133,905	133,905
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	120,312	120,312
Renaissance Technologies LLC	[2025-06-30]	SOLE	89,296	89,296
FMR LLC	[2025-06-30]	DFND	76,802	77,555
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	67,398	67,398
Two Sigma Investments LP	[2025-06-30]	SOLE	64,601	64,601
Two Sigma Advisers LP	[2025-06-30]	SOLE	61,101	62,501
Bank of New York Mellon Corp	[2025-06-30]	DFND	47,292	53,970
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