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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vivo Capital LLC	[2023-03-31]	SOLE	3,871,291.0	3,871,291.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,838,445.0	2,838,445.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	2,754,437.0	2,754,437.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	1,891,467.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	1,627,553.0
OrbiMed Advisors LLC	[2023-03-31]	SOLE	1,541,000.0	1,541,000.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	1,166,952.0	1,166,952.0
Newtyn Management LLC	[2023-03-31]	SOLE	1,115,110.0	1,115,110.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	1,049,153.0	1,049,153.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	924,265.0
Board of Trustees of The Leland Stanford Junior University	[2023-03-31]	SOLE	719,546.0	719,546.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	500,000.0	500,000.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	155,339.0	456,739.0
Hawkeye Capital Management LLC	[2023-03-31]	SOLE	415,039.0	415,039.0
Morgan Stanley	[2023-03-31]	DFND	276,033.0	306,402.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	283,085.0	283,085.0
BlackRock Inc.	[2023-03-31]	SOLE	274,430.0	274,430.0
Millennium Management LLC	[2023-03-31]	SOLE	245,411.0	245,411.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	225,816.0	225,816.0
JPMorgan Chase & Co	[2023-03-31]	DFND	189,306.0	189,306.0
Geode Capital Management LLC	[2023-03-31]	DFND	177,992.0	177,992.0
Velan Capital Investment Management LP	[2023-03-31]	SOLE	140,000.0	140,000.0
Privium Fund Management UK Ltd	[2023-03-31]	SOLE	116,516.0	116,516.0
Marquette Asset Management LLC	[2023-03-31]	SOLE	0.0	97,835.0
FMR LLC	[2023-03-31]	DFND	78,391.0	78,433.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	75,200.0	75,200.0
State Street Corp	[2023-03-31]	DFND	48,737.0	48,737.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	31,182.0
Bailard Inc	[2023-03-31]	SOLE	28,500.0	28,500.0
Man Group plc	[2023-03-31]	DFND	25,367.0	25,367.0
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