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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	28,939,395	28,939,395
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	2,502,531
RA Capital Management LP	[2025-06-30]	OTR	2,479,872	2,479,872
Citigroup Inc	[2025-06-30]	DFND	1,611,887	1,611,887
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	1,500,000	1,500,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,321,189
Deep Track Capital LP	[2025-06-30]	SOLE	1,040,115	1,040,115
Kynam Capital Management LP	[2025-06-30]	SOLE	1,028,341	1,028,341
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,000,000
BlackRock, Inc.	[2025-06-30]	SOLE	875,435	877,969
Diadema Partners LP	[2025-06-30]	SOLE	702,135	702,135
Peapod Lane Capital LLC	[2025-06-30]	SOLE	443,807	555,667
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	547,965	547,965
Renaissance Technologies LLC	[2025-06-30]	SOLE	495,500	495,500
Alyeska Investment Group LP	[2025-06-30]	SOLE	485,364	485,364
Millennium Management LLC	[2025-06-30]	SOLE	480,078	480,078
NAN FUNG TRINITY (HK) Ltd	[2025-06-30]	SOLE	463,654	463,654
Shay Capital LLC	[2025-06-30]	SOLE	415,000	415,000
UBS Group AG	[2025-06-30]	DFND	382,482	382,482
Geode Capital Management LLC	[2025-06-30]	DFND	311,721	311,721
JPMorgan Chase & Co	[2025-06-30]	DFND	210,122	210,122
Sphera Funds Management Ltd	[2025-06-30]	DFND	209,837	209,837
Goldman Sachs Group Inc	[2025-06-30]	DFND	201,312	201,312
Two Sigma Investments LP	[2025-06-30]	SOLE	179,591	179,591
Jane Street Group LLC	[2025-06-30]	DFND	148,180	148,180
Persistent Asset Partners Ltd	[2025-06-30]	SOLE	145,179	145,179
Northern Trust Corp	[2025-06-30]	DFND	141,424	141,424
Citadel Advisors LLC	[2025-06-30]	DFND	138,392	138,392
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	134,300	134,300
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	127,952	127,952
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